Twenty-five years ago, the first mammalian Transient Receptor Potential Canonical (TRPC)
channel was cloned, opening the vast horizon of the TRPC field. Today, we know that there …

It is now well established that antibodies have numerous potential benefits when developed
as therapeutics. Here, we evaluate the technical challenges of raising antibodies to …

Idiopathic pulmonary arterial hypertension (PAH) is a fatal and progressive disease.
Sustained vasoconstriction due to pulmonary arterial smooth muscle cell (PASMC) …

Pulmonary arterial hypertension (PAH) is due to progressive distal pulmonary artery (PA)
obstruction, leading to right ventricular hypertrophy and failure. Exacerbated store-operated …

Store-operated channels (SOCs) are highly selective Ca2+ channels that mediate Ca2+
influx in non-excitable and excitable (ie, skeletal and cardiac muscle) cells. These channels …

Background Salt‐sensitive hypertension is highly prevalent and associated with cardiorenal
damage. Large clinical trials have demonstrated that SGLT2 (sodium‐glucose cotransporter …

Transient receptor potentials (TRPs) are non-selective cation channels that are widely
expressed in vascular beds. They contribute to the Ca2+ influx evoked by a wide spectrum …

Hypertension is a highly prevalent chronic disease and the major risk factor for
cardiovascular diseases, the leading cause of death worldwide. Hypertension is …

The human TRP protein family comprises a family of 27 cation channels with diverse
permeation and gating properties. The common theme is that they are very important …

The transient receptor potential ion channels support Ca 2+ permeation in many organs,
including the heart, brain, and kidney. Genetic mutations in transient receptor potential …