Few human pathogens have been the focus of as much concentrated worldwide attention as
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of COVID-19. Its …

Vaccination affords protection from disease by activating pathogen-specific immune cells
and facilitating the development of persistent immunologic memory toward the vaccine …

CD25, the high-affinity interleukin-2 (IL-2) receptor α chain, is rapidly upregulated by antigen-
specific CD8+ T cells after T cell receptor stimulation. Here, we demonstrate that during an …

Six years have passed since the outbreak of severe acute respiratory syndrome (SARS).
Previous studies indicated that specific Abs to SARS-related coronavirus (SARS-CoV) …

In response to viral infection, naive CD8+ T cells proliferate and differentiate into cytotoxic
and cytokine-producing effector cells. Here we showed that the transcription factor Blimp-1 …

An important question in memory development is understanding the differences between
effector CD8 T cells that die versus effector cells that survive and give rise to memory cells …

Human bone marrow–derived mesenchymal stromal cells (MSCs) inhibit proliferation of
activated T cells, and IFN-γ plays an important role in this process. This IFN-γ–licensed veto …

Effector cells derived from central memory CD8+ T cells were reported to engraft and survive
better than those derived from effector memory populations, suggesting that they are …

The immunostimulants 3-O-desacyl-4'-monophosphoryl lipid A (MPL) and the saponin QS-
21 are part of licensed or candidate vaccines. MPL and QS-21 directly affect the innate …

Memory T cells exhibit superior responses to pathogens and tumors compared with their
naive counterparts. Memory is typically generated via an immune response to a foreign …