MAIT cells: new guardians of the liver
A Kurioka, LJ Walker, P Klenerman… - Clinical & translational …, 2016 - Wiley Online Library
The liver is an important immunological organ that remains sterile and tolerogenic in
homeostasis, despite continual exposure to non‐self food and microbial‐derived products …
homeostasis, despite continual exposure to non‐self food and microbial‐derived products …
Co-dependents: MR1-restricted MAIT cells and their antimicrobial function
MC Gold, DM Lewinsohn - Nature Reviews Microbiology, 2013 - nature.com
Mucosal-associated invariant T (MAIT) cells are a unique T cell subset in mammals. They
are present at high frequencies at mucosal tissue sites and have an intrinsic capacity to …
are present at high frequencies at mucosal tissue sites and have an intrinsic capacity to …
Polyclonal mucosa-associated invariant T cells have unique innate functions in bacterial infection
Mucosa-associated invariant T (MAIT) cells are a unique population of αβ T cells in
mammals that reside preferentially in mucosal tissues and express an invariant Vα paired …
mammals that reside preferentially in mucosal tissues and express an invariant Vα paired …
MAIT cell-MR1 reactivity is highly conserved across multiple divergent species
MD Edmans, TK Connelley, S Morgan… - Journal of Biological …, 2024 - jbc.org
Mucosal-associated invariant T (MAIT) cells are a subset of unconventional T cells that
recognize small molecule metabolites presented by major histocompatibility complex class I …
recognize small molecule metabolites presented by major histocompatibility complex class I …
Endogenous MHC-related protein 1 is transiently expressed on the plasma membrane in a conformation that activates mucosal-associated invariant T cells
The development of mucosal-associated invariant T (MAIT) cells is dependent upon the
class Ib molecule MHC-related protein 1 (MR1), commensal bacteria, and a thymus …
class Ib molecule MHC-related protein 1 (MR1), commensal bacteria, and a thymus …
Role of MAIT cells in the immunopathogenesis of inflammatory diseases: new players in old game
Current advances in immunology have led to the identification of a population of novel
innate immune T cells, called mucosa-associated invariant T (MAIT) cells. The cells in …
innate immune T cells, called mucosa-associated invariant T (MAIT) cells. The cells in …
MAIT cells and pathogen defense
SC Cowley - Cellular and molecular life sciences, 2014 - Springer
Mucosa-associated invariant T (MAIT) cells are a unique population of innate T cells that are
abundant in humans. These cells possess an evolutionarily conserved invariant T cell …
abundant in humans. These cells possess an evolutionarily conserved invariant T cell …
Association of MR1 protein, an MHC class I-related molecule, with β2-microglobulin
H Yamaguchi, K Hashimoto - Biochemical and biophysical research …, 2002 - Elsevier
MR1 is a major histocompatibility complex (MHC) class I-related gene conserved among
mammals, and its predicted amino acid sequence is relatively closer to the classical MHC …
mammals, and its predicted amino acid sequence is relatively closer to the classical MHC …
Patterns of nonclassical MHC antigen presentation
TH Hansen, S Huang, PL Arnold, DH Fremont - Nature immunology, 2007 - nature.com
The identification of pattern-recognition receptors that selectively respond to evolutionarily
conserved chemical (often pathogen-derived) moieties has provided key insight into how …
conserved chemical (often pathogen-derived) moieties has provided key insight into how …
[HTML][HTML] Conservation of mucosal associated invariant T (MAIT) cells and the MR1 restriction element in ruminants, and abundance of MAIT cells in spleen
Abstract MHC-related protein 1 (MR1) is a highly conserved MHC class I-like molecule.
Human and murine mucosal associated invariant T (MAIT) cells are restricted by MR1 and …
Human and murine mucosal associated invariant T (MAIT) cells are restricted by MR1 and …