Electroneutral cation-Cl− cotransporters compose a family of solute carriers in which cation
(Na+ or K+) movement through the plasma membrane is always accompanied by Cl− in a 1 …

Inhibition of the renin-angiotensin-aldosterone system (RAAS) is one of the most powerful
maneuvers to slow progression of renal disease. Angiotensin II (AngII) has emerged in the …

The renin-angiotensin-aldosterone system is one of the most important systems in
cardiovascular control and in the pathogenesis of cardiovascular diseases. Therefore, it is …

The mineralocorticoid aldosterone is a major regulator of sodium transport in target epithelia
and contributes to the control of blood pressure and cardiac function. It specifically functions …

Sodium reabsorption and potassium secretion in the distal convoluted tubule and in the
connecting tubule can maintain the homeostasis of the body, especially when dietary …

The distal tubule of the mammalian kidney can be defined as the nephron segment between
the macula densa region and the cortical collecting tubule. It comprises several …

Our understanding of urinary concentrating and diluting mechanisms at the end of the 20th
century was based largely on data from renal micropuncture studies, isolated perfused …

Body sodium (Na) levels must be maintained within a narrow range for the correct
functioning of the organism (Na homeostasis). Na disorders include not only elevated levels …

Dietary salt intake controls epithelial Na+ channel (ENaC)-mediated Na+ reabsorption in the
distal nephron by affecting status of the renin-angiotensin-aldosterone system (RAAS) …

The intrarenal renin–angiotensin system is critical for the regulation of tubule sodium
reabsorption, renal haemodynamics and blood pressure. The excretion of renin in urine can …