The effects of cadmium exposure in the induction of inflammation

N Hossein-Khannazer, G Azizi, S Eslami… - …, 2020 - Taylor & Francis
Inflammation is a physiological process essential for maintaining homeostatic mechanisms
in human, but however, exaggerated inflammatory responses are closely related to many …

Inflammaging and complement system: a link between acute kidney injury and chronic graft damage

R Franzin, A Stasi, M Fiorentino, G Stallone… - Frontiers in …, 2020 - frontiersin.org
The aberrant activation of complement system in several kidney diseases suggests that this
pillar of innate immunity has a critical role in the pathophysiology of renal damage of …

Histone acetylation and DNA methylation in ischemia/reperfusion injury

J Tang, S Zhuang - Clinical Science, 2019 - portlandpress.com
Abstract Ischemic/reperfusion (I/R) injury causes a series of serious clinical problems
associated with high morbidity and mortality in various disorders, such as acute kidney injury …

[HTML][HTML] Epigenetic memory contributing to the pathogenesis of AKI-to-CKD transition

F Tanemoto, M Nangaku, I Mimura - Frontiers in Molecular …, 2022 - frontiersin.org
Epigenetic memory, which refers to the ability of cells to retain and transmit epigenetic marks
to their daughter cells, maintains unique gene expression patterns. Establishing …

Cellular senescence in ischemia/reperfusion injury

C Chen, M Zheng, H Hou, S Fang, L Chen, J Yang… - Cell Death …, 2022 - nature.com
Abstract Ischemia/reperfusion (IR) injury, a main reason of mortality and morbidity
worldwide, occurs in many organs and tissues. As a result of IR injury, senescent cells can …

Lung allograft epithelium DNA methylation age is associated with graft chronologic age and primary graft dysfunction

DT Dugger, DR Calabrese, Y Gao, F Deiter… - Frontiers in …, 2021 - frontiersin.org
Advanced donor age is a risk factor for poor survival following lung transplantation.
However, recent work identifying epigenetic determinants of aging has shown that biologic …

[HTML][HTML] DNA methylation-and telomere-based biological age estimation as markers of biological aging in donors kidneys

S Pavanello, M Campisi, P Rigotti, MD Bello… - Frontiers in …, 2022 - frontiersin.org
The biological age of an organ may represent a valuable tool for assessing its quality,
especially in the elder. We examined the biological age of the kidneys [right (RK) and left …

[HTML][HTML] BET proteins: an approach to future therapies in transplantation

B Suarez-Alvarez, RM Rodriguez… - American Journal of …, 2017 - Elsevier
In order to develop new efficient therapies for organ transplantation, it is essential to acquire
a comprehensive knowledge of the molecular mechanisms and processes, such as immune …

[HTML][HTML] Longitudinal epigenome-wide analysis of kidney transplant recipients pretransplant and posttransplant

LJ Smyth, KR Kerr, J Kilner, ÁE McGill… - Kidney international …, 2023 - Elsevier
Introduction Kidney transplantation remains the gold standard of treatment for end-stage
renal disease (ESRD), with improved patient outcomes compared with dialysis. Epigenome …

Lupus, DNA methylation, and air pollution: a malicious triad

L Rasking, C Roelens, B Sprangers… - International Journal of …, 2022 - mdpi.com
The pathogenesis of systemic lupus erythematosus (SLE) remains elusive to this day;
however, genetic, epigenetic, and environmental factors have been implicated to be …