Phagocytosis of apoptotic cells, termed efferocytosis, is critical for tissue homeostasis and
drives anti-inflammatory programming in engulfing macrophages. Here, we assess …

Resolvins are specialized pro-resolving mediators derived from omega-3 fatty acids that can
suppress several cancer-related molecular pathways, including important activation of …

Macrophages are immune myeloid cells with an extreme ability to modulate their phenotype
in response to insults and/or pathogens. The immunomodulatory capacity of macrophages is …

Abstract Peroxisome Proliferator-Activated Receptors-γ (PPAR-γ), a ligand-activated
transcription factor, suggested having anti-inflammatory effects by activating the target genes …

The signal transducer and activator of transcription 6 (STAT6) transcription factor promotes
activation of the peroxisome proliferator-activated receptor gamma (PPARγ) pathway in …

Naringin exhibited various pharmacological activities. However, its biological function and
underlying mechanism in regulating macrophage polarization remain elusive. This study …

Eosinophils are multifunctional, evolutionary conserved leukocytes that are involved in a
plethora of responses ranging from regulation of tissue homeostasis, host defense and …

Peroxisome proliferator–activated receptors-γ (PPAR-γ), a ligand-activated transcription
factor, activated by several ligands like fatty acids (linoleic acid being the most common) or …

Rheumatoid arthritis (RA) is an autoimmune disorder characterized by chronic inflammation
of the synovial joints and the dysfunction of regulatory T cells (Tregs) in the peripheral blood …

Background Proline-serine-threonine phosphatase-interacting protein 2 (PSTPIP2) plays a
role in inflammatory disease. In diabetes, very little is known about PSTPIP2 until now …