Causal mapping of human brain function

SH Siddiqi, KP Kording, J Parvizi, MD Fox - Nature reviews …, 2022 - nature.com
Mapping human brain function is a long-standing goal of neuroscience that promises to
inform the development of new treatments for brain disorders. Early maps of human brain …

Mapping symptoms to brain networks with the human connectome

MD Fox - New England Journal of Medicine, 2018 - Mass Medical Soc
The Brain Connectome and New Methods of Lesion Analysis Complex neurologic and
psychiatric syndromes cannot be understood on the basis of focal brain lesions. Functional …

Lead-DBS v2: Towards a comprehensive pipeline for deep brain stimulation imaging

A Horn, N Li, TA Dembek, A Kappel, C Boulay, S Ewert… - Neuroimage, 2019 - Elsevier
Deep brain stimulation (DBS) is a highly efficacious treatment option for movement disorders
and a growing number of other indications are investigated in clinical trials. To ensure …

Connectivity predicts deep brain stimulation outcome in P arkinson disease

A Horn, M Reich, J Vorwerk, N Li, G Wenzel… - Annals of …, 2017 - Wiley Online Library
Objective The benefit of deep brain stimulation (DBS) for Parkinson disease (PD) may
depend on connectivity between the stimulation site and other brain regions, but which …

Post-stroke deficit prediction from lesion and indirect structural and functional disconnection

A Salvalaggio, M De Filippo De Grazia, M Zorzi… - Brain, 2020 - academic.oup.com
Behavioural deficits in stroke reflect both structural damage at the site of injury, and
widespread network dysfunction caused by structural, functional, and metabolic …

Prospective validation that subgenual connectivity predicts antidepressant efficacy of transcranial magnetic stimulation sites

A Weigand, A Horn, R Caballero, D Cooke, AP Stern… - Biological …, 2018 - Elsevier
Background The optimal target in the dorsolateral prefrontal cortex for treating depression
with repetitive transcranial magnetic stimulation (rTMS) remains unknown. Better efficacy …

Revisiting the functional anatomy of the human brain: toward a meta-networking theory of cerebral functions

G Herbet, H Duffau - Physiological Reviews, 2020 - journals.physiology.org
For more than one century, brain processing was mainly thought in a localizationist
framework, in which one given function was underpinned by a discrete, isolated cortical …

Toward an electrophysiological “sweet spot” for deep brain stimulation in the subthalamic nucleus

A Horn, WJ Neumann, K Degen… - Human brain …, 2017 - Wiley Online Library
Enhanced beta‐band activity recorded in patients suffering from Parkinson's Disease (PD)
has been described as a potential physiomarker for disease severity. Beta power is …

A human depression circuit derived from focal brain lesions

JL Padmanabhan, D Cooke, J Joutsa, SH Siddiqi… - Biological …, 2019 - Elsevier
Background Focal brain lesions can lend insight into the causal neuroanatomical substrate
of depression in the human brain. However, studies of lesion location have led to …

Science denial and COVID conspiracy theories: potential neurological mechanisms and possible responses

BL Miller - Jama, 2020 - jamanetwork.com
2019 (COVID-19) has been dismal, characterized by antimask behavior, antivaccine beliefs,
conspiracy theories about the origins of COVID-19, and vocal support by elected officials for …