I. Origin of the Insulin Sensitivity Concept H ISTORICALLY, the study of the pathogenesis of
diabetes mellitus was in the traditional pattern of endocrinology: removal of the pancreas led …

An overview of some of the mathematical models appearing in the literature for use in the
glucose-insulin regulatory system in relation to diabetes is given, enhanced with a survey on …

The quantitative contributions of pancreatic responsiveness and insulin sensitivity to glucose
tolerance were measured using the" minimal modeling technique" in 18 lean and obese …

Insulin sensitivity and pancreatic responsivity are the two main factors controlling glucose
tolerance. We have proposed a method for measuring these two factors, using computer …

We used the minimal model technique to obtain concurrent measurements of whole-body
insulin sensitivity and pancreatic B-cell responsiveness to glucose during the third trimester …

Diabetes is a disease of the glucose regulatory system that is associated with increased
morbidity and early mortality. The primary variables of this system are β-cell mass, plasma …

Given the extreme increase in prediabetes, type 2 diabetes, and the potential for metabolic
syndrome in obese youth, identifying simplified indexes for assessing stimulated insulin …

The quantitative assessment of insulin sensitivity (IS) and β-cell function (BCF) is
fundamental in the study of metabolic disorders. The most relevant experimental tests and …

To identify the pathogenic factors responsible for glucose intolerance of aging, we measured
a variety of metabolic parameters, including insulin sensitivity and islet cell function, in 10 …

Mathematical modeling of the glucose–insulin feedback system is necessary to the
understanding of the homeostatic control, to analyze experimental data, to identify and …