The aggregation of proteins into amyloid fibrils and their deposition into plaques and
intracellular inclusions is the hallmark of amyloid disease. The accumulation and deposition …

Neurodegenerative disorders and type 2 diabetes are global epidemics compromising the
quality of life of millions worldwide, with profound social and economic implications. Despite …

A common feature of many neurodegenerative diseases is the deposition of β-sheet-rich
amyloid aggregates formed by proteins specific to these diseases. These protein aggregates …

Background Definite diagnosis of sporadic Creutzfeldt–Jakob disease in living patients
remains a challenge. A test that detects the specific marker for Creutzfeldt–Jakob disease …

Most common neurodegenerative diseases feature deposition of protein amyloids and
degeneration of brain networks. Amyloids are ordered protein assemblies that can act as …

Prions are proteins that acquire alternative conformations that become self-propagating.
Transformation of proteins into prions is generally accompanied by an increase in β-sheet …

Prions are notorious protein-only infectious agents that cause invariably fatal brain diseases
following silent incubation periods that can span a lifetime. These diseases can arise …

Failure of elimination of proteins from the brain is a major feature in many
neurodegenerative diseases. Insoluble proteins accumulate in brain parenchyma and in …

Structures of the infectious form of prion protein (eg PrP Sc or PrP-Scrapie) remain poorly
defined. The prevalent structural models of PrP Sc retain most of the native α-helices of the …

The transformation of astrocytes into reactive states constitutes a biological response of the
central nervous system under a variety of pathological insults. Astrocytes display diverse …