In vivo two-photon calcium imaging (2PCI) is a technique used for recording neuronal
activity in the intact brain. It is based on the principle that, when neurons fire action …

Optogenetics ushered in a revolution in how neuroscientists interrogate brain function.
Because of technical limitations, the majority of optogenetic studies have used low spatial …

We developed a miniaturized two-photon microscope (MINI2P) for fast, high-resolution,
multiplane calcium imaging of over 1,000 neurons at a time in freely moving mice. With a …

Recent progress in fluorescence imaging allows neuroscientists to observe the dynamics of
thousands of individual neurons, identified genetically or by their connectivity, across …

Brain-machine interfaces (BMIs) combine methods, approaches, and concepts derived from
neurophysiology, computer science, and engineering in an effort to establish real-time …

We have developed a miniature two-photon microscope equipped with an axial scanning
mechanism and a long-working-distance miniature objective to enable multi-plane imaging …

Bidirectional interfacing with the nervous system enables neuroscience research, diagnosis,
and therapy. This two-way communication allows us to monitor the state of the brain and its …

Quantitative phase imaging (QPI) of transparent samples plays an essential role in multiple
biomedical applications, and miniaturizing these systems will enable their adoption into …

Miniature fluorescence microscopes are a standard tool in systems biology. However,
widefield miniature microscopes capture only 2D information, and modifications that enable …

Since the introduction of calcium imaging to monitor neuronal activity with single-cell
resolution, optical imaging methods have revolutionized neuroscience by enabling …