Phenyl-γ-valerolactones and phenylvaleric acids, the main colonic metabolites of flavan-3-ols: Synthesis, analysis, bioavailability, and bioactivity

P Mena, L Bresciani, N Brindani, IA Ludwig… - Natural Product …, 2019 - pubs.rsc.org
Covering: 1958 to June 2018 Phenyl-γ-valerolactones (PVLs) and their related
phenylvaleric acids (PVAs) are the main metabolites of flavan-3-ols, the major class of …

[HTML][HTML] Why is it important to understand the nature and chemistry of tannins to exploit their potential as nutraceuticals?

S Molino, MP Francino, JÁR Henares - Food research international, 2023 - Elsevier
Tannins comprise a large group of polyphenols that can differ widely in chemical
composition and molecular weight. The use of tannins dates back to antiquity, but it is only in …

[HTML][HTML] Revisiting the bioavailability of flavan-3-ols in humans: A systematic review and comprehensive data analysis

G Di Pede, P Mena, L Bresciani, M Achour… - Molecular Aspects of …, 2023 - Elsevier
This systematic review summarizes findings from human studies investigating the different
routes of absorption, metabolism, distribution and excretion (ADME) of dietary flavan-3-ols …

Rethinking the mechanism of the health benefits of proanthocyanidins: Absorption, metabolism, and interaction with gut microbiota

W Tao, Y Zhang, X Shen, Y Cao, J Shi… - … Reviews in Food …, 2019 - Wiley Online Library
Proanthocyanidins, as the oligomers or polymers of flavan‐3‐ol, are widely discovered in
plants such as fruits, vegetables, cereals, nuts, and leaves, presenting a major part of dietary …

Health benefits of proanthocyanidins linking with gastrointestinal modulation: An updated review

X Zhang, X Song, X Hu, F Chen, C Ma - Food Chemistry, 2023 - Elsevier
Proanthocyanidins (PACs) are the bioactive components naturally present in daily diet,
especially in fruits and vegetables. Multiple pieces of evidence suggested that ingestion of …

UHPLC-HRMS spectrometric analysis: Method validation and plasma and urinary metabolite identification after mango pulp intake

S Cáceres-Jiménez, R Rodríguez-Solana… - Journal of Agricultural …, 2023 - ACS Publications
After an acute intake of 300 g of mango purée by 10 subjects, 0 and 24 h urine and plasma
samples were analyzed by high-performance liquid chromatography–high-resolution mass …

[HTML][HTML] Exploring and disentangling the production of potentially bioactive phenolic catabolites from dietary (poly) phenols, phenylalanine, tyrosine and …

MN Clifford, IA Ludwig, G Pereira-Caro, L Zeraik… - Redox Biology, 2024 - Elsevier
Following ingestion of fruits, vegetables and derived products,(poly) phenols that are not
absorbed in the upper gastrointestinal tract pass to the colon, where they undergo …

Pancreatic lipase and α-amylase inhibitory activity of extracts from selected plant materials after gastrointestinal digestion in vitro

J Siegień, T Buchholz, D Popowski, S Granica… - Food Chemistry, 2021 - Elsevier
A screening of inhibitory activity of α-amylase, as well as pancreatic lipase (PL), under the
influence of aqueous and ethanolic preparations from 12 plant materials was performed …

Metabolomics technologies for the identification and quantification of dietary phenolic compound metabolites: an overview

A López-Yerena, I Domínguez-López… - Antioxidants, 2021 - mdpi.com
In the search for natural products with properties that may protect against or slow down
chronic and degenerative diseases (eg, cancer, and cardiovascular and neurodegenerative …

Plant leaf proanthocyanidins: From agricultural production by-products to potential bioactive molecules

W Zhou, L Zhao, K Wang, CMGC Renard… - Critical Reviews in …, 2024 - Taylor & Francis
Proanthocyanidins (PAs) are a class of polymers composed of flavan-3-ol units that have a
variety of bioactivities, and could be applied as natural biologics in food, pharmaceuticals …