Many active pharmaceutical ingredients (APIs) exhibit poor solubility and low dissolution
rates in aqueous environments such as the luminal fluids of the gastrointestinal tract. The …

Nanoconjugations have been demonstrated to be a dominant strategy for drug delivery and
biomedical applications. In this review, we intend to describe several strategies for drug …

In addition to a number of highly soluble drugs, most new chemical entities under
development are poorly water-soluble drugs generally characterized by an insufficient …

Physicochemical characterization is a crucial step for the successful development of solid
dispersions, including the determination of drug crystallinity and molecular interactions …

The objective of this study was to formulate aripiprazole (ARI)-loaded pH-modulated solid
dispersions (SD) to enhance solubility, dissolution, and bioavailability via hot-melt extrusion …

Although solid dispersions have been reported as an efficient drug delivery system, the
design of specific dosage forms for pharmaceutical therapy is necessary to improve the …

The purpose of this study was to increase the dissolution of glycyrrhetinic acid (GA) by
preparing ternary solid dispersion (TSD) systems containing alkalizers, and to explore the …

Importance of the field: Although the solid dispersion method has been known to increase
the dissolution rate of poorly water-soluble drugs by dispersing them in hydrophilic carriers …

The roles of acidifiers in polyvinylpyrrolidone-based solid dispersions and physical mixtures
were originally investigated on dissolution rate of drug, acidifier release, structural …

The aims of this study are to increase and explain the mechanism of dissolution
enhancement of isradipine using the sonoprecipitation method for stable nanosuspensions …