Hereditary palmoplantar keratodermas (PPK s) comprise a large and heterogeneous group
of disorders characterized by persistent thickening of the epidermis at palmar and plantar …

The CRISPR-based genome editing holds immense potential to fix disease-causing
mutations, however, must also handle substantial natural genetic variations between …

Background No specific or curative therapy exists for hereditary palmoplantar keratoderma
(hPPK), which can profoundly alter patient quality of life, leading sometimes to severe …

Background Mendelian disorders of cornification (MeDOC) are a group of heterogeneous
genodermatoses with different genetic bases. The pathogenesis of a substantial group of …

Epidermolytic palmoplantar keratoderma (EPPK), a highly penetrant autosomal dominant
genodermatosis, is characterized by diffuse keratoses on palmplantar epidermis. The keratin …

CRISPR/Cas9 has been confirmed as a distinctly efficient, simple-to-configure, highly
specific genome-editing tool that has been used to treat monogenetic disorders …

Allele-specific siRNAs (ASP-siRNAs) have emerged as promising therapeutic molecules
owing to their selectivity to inhibit the mutant allele or associated single-nucleotide …

Background Advanced paternal age (APA) is associated with decreased fertility, but the
mechanism underlying APA remains unknown. CircRNAs have been reported to be ideal …

Fibrotic eye diseases, a series of severe oculopathy, that will destroy normal ocular
refractive media and imaging structures. It is characterized by the transformation of the …

Background/Aims: Epidermolytic palmoplantar keratoderma (EPPK) is an autosomal
dominant genodermatosis. It is characterized by diffuse yellow keratoses on the …