Drosophila as a Model for Infectious Diseases

JM Harnish, N Link, S Yamamoto - International journal of molecular …, 2021 - mdpi.com
The fruit fly, Drosophila melanogaster, has been used to understand fundamental principles
of genetics and biology for over a century. Drosophila is now also considered an essential …

Subversion of host kinases: a key network in cellular signaling hijacked by Helicobacter pylori CagA

N Tegtmeyer, M Neddermann, CI Asche… - Molecular …, 2017 - Wiley Online Library
Helicobacter pylori is a paradigm of persistent pathogens and major risk factor for
developing severe diseases including adenocarcinoma in the human stomach. An important …

Four Chromosomal Type IV Secretion Systems in Helicobacter pylori: Composition, Structure and Function

W Fischer, N Tegtmeyer, K Stingl… - Frontiers in Microbiology, 2020 - frontiersin.org
The pathogenic bacterium Helicobacter pylori is genetically highly diverse and a major risk
factor for the development of peptic ulcer disease and gastric adenocarcinoma in humans …

[HTML][HTML] Tight junction disruption: Helicobacter pylori and dysregulation of the gastric mucosal barrier

TJ Caron, KE Scott, JG Fox… - World Journal of …, 2015 - ncbi.nlm.nih.gov
Long-term chronic infection with Helicobacter pylori (H. pylori) is a risk factor for gastric
cancer development. In the multi-step process that leads to gastric cancer, tight junction …

Admixture Mapping of Alzheimer's disease in Caribbean Hispanics identifies a new locus on 22q13. 1

C Kizil, S Sariya, YA Kim, F Rajabli, E Martin… - Molecular …, 2022 - nature.com
Late-onset Alzheimer's disease (LOAD) is significantly more frequent in Hispanics than in
non-Hispanic Whites. Ancestry may explain these differences across ethnic groups. To this …

RNA methyltransferase NSun2 deficiency promotes neurodegeneration through epitranscriptomic regulation of tau phosphorylation

YA Kim, T Siddiqui, J Blaze, MI Cosacak, T Winters… - Acta …, 2023 - Springer
Epitranscriptomic regulation adds a layer of post-transcriptional control to brain function
during development and adulthood. The identification of RNA-modifying enzymes has …

CagA–ASPP2 complex mediates loss of cell polarity and favors H. pylori colonization of human gastric organoids

L Buti, C Ruiz-Puig, D Sangberg… - Proceedings of the …, 2020 - National Acad Sciences
The main risk factor for stomach cancer, the third most common cause of cancer death
worldwide, is infection with Helicobacter pylori bacterial strains that inject cytotoxin …

Human pathogenic bacteria, fungi, and viruses in Drosophila Disease modeling, lessons, and shortcomings

S Panayidou, E Ioannidou, Y Apidianakis - Virulence, 2014 - Taylor & Francis
Drosophila has been the invertebrate model organism of choice for the study of innate
immune responses during the past few decades. Many Drosophila–microbe interaction …

The bacterial virulence factor CagA induces microbial dysbiosis that contributes to excessive epithelial cell proliferation in the Drosophila gut

TA Jones, DZ Hernandez, ZC Wong… - PLoS …, 2017 - journals.plos.org
Gut microbiota facilitate many aspects of human health and development, but dysbiotic
microbiota can promote hyperplasia and inflammation and contribute to human diseases …

Transgenic Expression of the Helicobacter pylori Virulence Factor CagA Promotes Apoptosis or Tumorigenesis through JNK Activation in Drosophila

AM Wandler, K Guillemin - 2012 - journals.plos.org
Gastric cancer development is strongly correlated with infection by Helicobacter pylori
possessing the effector protein CagA. Using a transgenic Drosophila melanogaster model …