Context The role of adjuvant chemotherapy (AC) or neoadjuvant chemotherapy (NC)
remains poorly defined for the management of upper tract urothelial carcinoma (UTUC) …

Upper tract urothelial carcinomas (UTUCs) consist of 5%–10% of all urothelial carcinomas,
the rest being urothelial carcinomas of the bladder (UCB). There is increasing evidence to …

Purpose The combination of gemcitabine plus cisplatin (GC) is a standard regimen in
patients with locally advanced or metastatic urothelial cancer. A phase I/II study suggested …

Secreted protein acidic and rich in cysteine (SPARC) has been implicated in multiple
aspects of human cancer. However, its role in bladder carcinogenesis and metastasis are …

The miR-200 microRNA family plays important tumor suppressive roles. The sole Drosophila
miR-200 ortholog, miR-8 plays conserved roles in Wingless, Notch and Insulin signaling …

The E11. 5 mouse metanephros is comprised of a T-stage ureteric epithelial tubule sub-
divided into tip and trunk cells surrounded by metanephric mesenchyme (MM). Tip cells are …

SPARC belongs to a class of extracellular matrix-associated proteins that have
counteradhesive properties. The ability of SPARC to modulate cell–cell and cell–matrix …

Urothelial cell carcinoma (UCC) is the fourth most common cancer worldwide, after prostate
(or breast), lung, and colorectal cancer. 1 Among UCC, upper tract urothelial carcinoma …

purpose. To investigate the role of SPARC in the regulation of the expression and deposition
of extracellular matrix (ECM) proteins in the lens capsule. methods. Wild-type (SP+/+) and …

Secreted protein acidic and rich in cystein (SPARC) is a secreted glycoprotein involved in
several biological processes such as tissue remodeling, embryonic development …