Psychedelic drugs including psilocybin, N, N ʹ-dimethyltryptamine (DMT) and lysergic acid
diethylamide (LSD) are undergoing a renaissance as potentially useful drugs for various …

HT receptors expressed throughout the human body are targets for established therapeutics
and various drugs in development. Their diversity of structure and function reflects the …

Summary Serotonin (5-hydroxytryptamine [5-HT]) 5-HT2-family receptors represent essential
targets for lysergic acid diethylamide (LSD) and all other psychedelic drugs. Although the …

Hallucinations limit widespread therapeutic use of psychedelics as rapidly acting
antidepressants. Here we profiled the non-hallucinogenic lysergic acid diethylamide (LSD) …

Psychedelics make up a group of psychoactive compounds that induce hallucinogenic
effects by activating the serotonin 2A receptor (5-HT2AR). Clinical trials have demonstrated …

4-Phosphoryloxy-N, N-dimethyltryptamine (psilocybin) is a naturally occurring tertiary amine
found in many mushroom species. Psilocybin is a prodrug for 4-hydroxy-N, N …

Abstract Seven-transmembrane receptors (7TMRs; also known as G protein-coupled
receptors) are the largest class of receptors in the human genome and are common targets …

Opioids are used for pain management despite the side effects that contribute to the opioid
crisis. The pursuit of non-addictive opioid analgesics remains unattained due to the …

Recent evidence suggests that psychedelic drugs can exert beneficial effects on anxiety,
depression, and ethanol and nicotine abuse in humans. However, their hallucinogenic side …

Over the past decade, psychedelic compounds have emerged as potentially transformative
therapeutics for a variety of intractable neuropsychiatric conditions. However, historically …