Significant advances in the understanding of the genetic abnormalities that lead to the
development, progression, and metastasis of neoplastic diseases has raised the promise of …

The most prevalent forms of bone cancer are osteosarcoma, chondrosarcoma, and Ewing's
sarcoma. Although chemotherapy and radiotherapy have replaced traditional surgical …

Many microRNAs (miRNAs), posttranscriptional regulators of numerous cellular processes
and developmental events, are downregulated in tumors. However, their role in …

Abstract Hypoxia inducible factor-1 (HIF-1) is the major transcription factor and key regulator
of adoptive responses to hypoxia. Although it usually promotes tumor cell survival under …

Genetic mutations in TP53 contribute to human malignancies through various means. To
date, there have been a variety of therapeutic strategies targeting p53, including gene …

Development of chemotherapeutic treatment modalities resulted in a dramatic increase in
the survival of children with many types of cancer. Still, in case of some pediatric cancer …

Alveolar and embryonal rhabdomyosarcomas are childhood tumors that do not respond well
to current chemotherapies. Here, we report that the glycolytic inhibitor 2-deoxyglucose (2 …

Gene therapy is most often described as a technique for introducing the foreign genetic
material into cells with a correction of a dysfunctional gene as its final goal. Today, it is well …

Ultrasound-targeted microbubble destruction (UTMD) technique can be potentially used for
non-viral delivery of gene therapy. Targeting wild-type p53 (wtp53) tumor suppressor gene …

Background Diverse functions of microRNAs (miRNAs), including effects on tumorigenesis,
proliferation, and differentiation, have been reported, and several miRNAs have also been …