The dramatic recent advances in molecular biology, which have opened a new era in
medicine and biotechnology, rely on improved techniques to study large molecules …

This Review addresses methods for obtaining sequence information directly from
unamplified genomic length DNA. Our generic starting point is a large piece of DNA that …

During the last decade, capillary electrophoresis (CE) of DNA has undergone rapid
development. This improvement was especially important for DNA sequencing, where CE …

In step with novel technologies and methodologies that have reshaped chromatography in
recent years, this supplement reviews developments in HPLC, TLC, SFC, CCC, and other …

▪ Abstract The Human Genome Project and other major genomic sequencing projects have
pushed the development of sequencing technology. In the past six years alone, instrument …

Abstract Theory and numerical simulations play a major role in the development of improved
and novel separation methods. In some cases, computer simulations predict counterintuitive …

We report here a technology to carry out separations of a wide range of DNA fragments with
high speed and high resolution. The approach uses a nanoparticle medium, core-shell type …

DNA is a free‐draining polymer. This subtle but “unfortunate” property of highly charged
polyelectrolytes makes it impossible to separate nucleic acids by free‐flow electrophoresis …

Although electrophoresis is one of the basic methods of the modern molecular biology
laboratory, new ideas are being suggested at an accelerated rate, in large part because of …

Analytical Chemistry has changed its policy on its biannual reviews. Rather than providing
an encyclopedic listing of papers in a specific topic, authors are asked to focus their reviews …