[HTML][HTML] Withania somnifera (L.) Dunal: opportunity for clinical repurposing in COVID-19 management

A Saggam, K Limgaokar, S Borse… - Frontiers in …, 2021 - frontiersin.org
As the COVID-19 pandemic is progressing, the therapeutic gaps in conventional
management have highlighted the need for the integration of traditional knowledge systems …

Withaferin-A—A natural anticancer agent with pleitropic mechanisms of action

IC Lee, BY Choi - International journal of molecular sciences, 2016 - mdpi.com
Cancer, being the second leading cause of mortality, exists as a formidable health
challenge. In spite of our enormous efforts, the emerging complexities in the molecular …

Perturbation-response genes reveal signaling footprints in cancer gene expression

M Schubert, B Klinger, M Klünemann, A Sieber… - Nature …, 2018 - nature.com
Aberrant cell signaling can cause cancer and other diseases and is a focal point of drug
research. A common approach is to infer signaling activity of pathways from gene …

Ayurveda botanicals in COVID-19 management: An in silico multi-target approach

S Borse, M Joshi, A Saggam, V Bhat, S Walia… - Plos one, 2021 - journals.plos.org
The Coronavirus disease (COVID-19) caused by the virus SARS-CoV-2 has become a
global pandemic in a very short time span. Currently, there is no specific treatment or …

Withania somnifera: From prevention to treatment of cancer

DL Palliyaguru, SV Singh… - Molecular nutrition & food …, 2016 - Wiley Online Library
The identification of bioactive molecules that have potential to interrupt carcinogenesis
continues to garner research interest. In particular, molecules that have dietary origin are …

Evaluating anticancer properties of Withaferin A—a potent phytochemical

M Atteeq - Frontiers in Pharmacology, 2022 - frontiersin.org
Withaferin A is a C28 steroidal lactone derived from the plant Withania somnifera, commonly
known as Ashwagandha. Withaferin A has received great attention for its anticancer …

Withaferin A: a dietary supplement with promising potential as an anti-tumor therapeutic for cancer treatment-pharmacology and mechanisms

Z Xing, A Su, L Mi, Y Zhang, T He, Y Qiu… - Drug Design …, 2023 - Taylor & Francis
Cancer, as the leading cause of death worldwide, poses a serious threat to human health,
making the development of effective tumor treatments a significant challenge. Natural …

Natural withanolides in the treatment of chronic diseases

PT White, C Subramanian, HF Motiwala… - … and chronic diseases, 2016 - Springer
Withanolides, and in particular extracts from Withania somnifera, have been used for over
3,000 years in traditional Ayurvedic and Unani Indian medical systems as well as within …

Can Ashwagandha Benefit the Endocrine System?—A Review

M Wiciński, A Fajkiel-Madajczyk, Z Kurant… - International journal of …, 2023 - mdpi.com
Withania somnifera, also known as Ashwagandha, has been used in traditional medicine for
thousands of years. Due to the wide range of its activities, there has been interest in its …

Withaferin A: A Pleiotropic Anticancer Agent from the Indian Medicinal Plant Withania somnifera (L.) Dunal

S Kumar, SO Mathew, RP Aharwal, HS Tulli… - Pharmaceuticals, 2023 - mdpi.com
Cancer represents the second most deadly disease and one of the most important public
health concerns worldwide. Surgery, chemotherapy, radiation therapy, and immune therapy …