Ikaros and leukaemia
L Olsson, B Johansson - British journal of haematology, 2015 - Wiley Online Library
The IKZF 1 gene at 7p12. 2 codes for IKAROS (also termed IKZF 1), an essential
transcription factor in haematopoiesis involved primarily in lymphoid differentiation. Its …
transcription factor in haematopoiesis involved primarily in lymphoid differentiation. Its …
Evidence-based review of genomic aberrations in B-lymphoblastic leukemia/lymphoma: Report from the cancer genomics consortium working group for lymphoblastic …
YMN Akkari, H Bruyere, RT Hagelstrom… - Cancer Genetics, 2020 - Elsevier
Clinical management and risk stratification of B-lymphoblastic leukemia/lymphoma (B-
ALL/LBL) depend largely on identification of chromosomal abnormalities obtained using …
ALL/LBL) depend largely on identification of chromosomal abnormalities obtained using …
HAP1 loss confers l-asparaginase resistance in ALL by downregulating the calpain-1-Bid-caspase-3/12 pathway
JK Lee, SM Kang, X Wang, JL Rosales… - Blood, The Journal …, 2019 - ashpublications.org
Abstract l-Asparaginase (l-ASNase) is a strategic component of treatment protocols for acute
lymphoblastic leukemia (ALL). It causes asparagine deficit, resulting in protein synthesis …
lymphoblastic leukemia (ALL). It causes asparagine deficit, resulting in protein synthesis …
The clinical impact of IKZF1 deletions in paediatric B‐cell precursor acute lymphoblastic leukaemia is independent of minimal residual disease stratification in Nordic …
L Olsson, I Ivanov Öfverholm… - British journal of …, 2015 - Wiley Online Library
Paediatric B‐cell precursor acute lymphoblastic leukaemias (BCP ALL) with IKZF 1 deletions
(∆ IKZF 1) are associated with a poor outcome. However, there are conflicting data as to …
(∆ IKZF 1) are associated with a poor outcome. However, there are conflicting data as to …
Confirmation of Childhood Acute Lymphoblastic Leukemia Variants, ARID5B and IKZF1, and Interaction with Parental Environmental Exposures
Genome wide association studies (GWAS) have established association of ARID5B and
IKZF1 variants with childhood acute lymphoblastic leukemia (ALL). Epidemiological studies …
IKZF1 variants with childhood acute lymphoblastic leukemia (ALL). Epidemiological studies …
[HTML][HTML] IKZF1 deletions associate with CRLF2 overexpression leading to a poor prognosis in B-cell precursor acute lymphoblastic leukaemia
ALT Maciel, T da Conceição Barbosa, CB Blunck… - Translational …, 2022 - Elsevier
Abstract Cytokine Receptor-Like Factor 2 (CRLF2) overexpression occurs in 5-15% of B-cell
precursor acute lymphoblastic leukaemia (B-ALL). In∼ 50% of these cases, the mechanisms …
precursor acute lymphoblastic leukaemia (B-ALL). In∼ 50% of these cases, the mechanisms …
[HTML][HTML] Digital multiplex ligation-dependent probe amplification for detection of key copy number alterations in T-and B-cell lymphoblastic leukemia
A Benard-Slagter, I Zondervan, K de Groot… - The Journal of Molecular …, 2017 - Elsevier
Recurrent and clonal genetic alterations are characteristic of different subtypes of T-and B-
cell lymphoblastic leukemia (ALL), and several subtypes are strong independent predictors …
cell lymphoblastic leukemia (ALL), and several subtypes are strong independent predictors …
[HTML][HTML] Loss-of-function but not dominant-negative intragenic IKZF1 deletions are associated with an adverse prognosis in adult BCR-ABL-negative acute …
B Kobitzsch, N Gökbuget, S Schwartz, R Reinhardt… - …, 2017 - ncbi.nlm.nih.gov
Genetic alterations of the transcription factor IKZF1 (“IKAROS”) are detected in around 15–
30% of cases of BCR-ABL-negative B-cell precursor acute lymphoblastic leukemia. Different …
30% of cases of BCR-ABL-negative B-cell precursor acute lymphoblastic leukemia. Different …
Ikaros sets the threshold for negative B-cell selection by regulation of the signaling strength of the AKT pathway
PAH Ehm, S Horn, K Hoffer, M Kriegs, M Horn… - Cell Communication and …, 2024 - Springer
Inhibitory phosphatases, such as the inositol-5-phosphatase SHIP1 could potentially
contribute to B-cell acute lymphoblastic leukemia (B-ALL) by raising the threshold for …
contribute to B-cell acute lymphoblastic leukemia (B-ALL) by raising the threshold for …
The recombinome of IKZF1 deletions in B-cell precursor ALL
The occurrence of IKZF1 deletions increases the risk of relapse in patients with B-cell
precursor acute lymphoblastic leukemia (BCPALL)[1, 2]. Therefore, the development of …
precursor acute lymphoblastic leukemia (BCPALL)[1, 2]. Therefore, the development of …