The urokinase‐type plasminogen activator (u‐PA) system consists of the serine proteinases
plasmin and u‐PA; the serpin inhibitors α2‐anti‐plasmin, PAI‐1 and PAI‐2; and the u‐PA …

Generation of the serine proteinase plasmin from the extracellular zymogen plasminogen
can be catalyzed by either of two other serine proteinases, the urokinase-and tissue-type …

Urokinase-type plasminogen activator receptor (uPAR) binds the urokinase-type
plasminogen activator (uPA) and facilitates a proteolytic cascade focused at the cell surface …

Currently, there are several studies supporting the role of urokinase‐type plasminogen
activator (uPA) system in cancer. The association of uPA to its receptor triggers the …

Blood coagulation can be initiated by two pathways: the extrinsic pathway, which is triggered
by release of tissue factor from the site of injury, and the intrinsic system, which is stimulated …

The urokinase receptor (uPAR) coordinates plasmin-mediated cell-surface proteolysis and
promotes cellular adhesion via a binding site for vitronectin on uPAR. Because vitronectin …

Tissue factor (TF), the initiating cell surface receptor of the coagulation cascade, plays
important roles in embryogenesis, angiogenesis, and tumor cell metastasis. It is …

Cell migration involves the integrins, their extracellular matrix ligands, and pericellular
proteolytic enzyme systems. We have studied the role of plasminogen activator inhibitor-1 …

The urokinase plasminogen activator (uPA) interacts with its cell surface receptor (uPAR),
providing an inducible, localized cell surface proteolytic activity, thereby promoting cellular …

TGF‐β strongly promotes local tumor progression in advanced epithelial tumors, though the
underlying mechanisms are poorly understood. In the present study, we demonstrate the …