Modeling and structure determination of homo-oligomeric proteins: An overview of challenges and current approaches
A Gaber, M Pavšič - International journal of molecular sciences, 2021 - mdpi.com
Protein homo-oligomerization is a very common phenomenon, and approximately half of
proteins form homo-oligomeric assemblies composed of identical subunits. The vast majority …
proteins form homo-oligomeric assemblies composed of identical subunits. The vast majority …
[PDF][PDF] Applications of contact predictions to structural biology
Evolutionary pressure on residue interactions, intramolecular or intermolecular, that are
important for protein structure or function can lead to covariance between the two positions …
important for protein structure or function can lead to covariance between the two positions …
Automated evaluation of quaternary structures from protein crystals
A correct assessment of the quaternary structure of proteins is a fundamental prerequisite to
understanding their function, physico-chemical properties and mode of interaction with other …
understanding their function, physico-chemical properties and mode of interaction with other …
[HTML][HTML] MCDB: A comprehensive curated mitotic catastrophe database for retrieval, protein sequence alignment, and target prediction
L Zhang, L Zhang, Y Guo, M Xiao, L Feng… - … Pharmaceutica Sinica B, 2021 - Elsevier
Mitotic catastrophe (MC) is a form of programmed cell death induced by mitotic process
disorders, which is very important in tumor prevention, development, and drug resistance …
disorders, which is very important in tumor prevention, development, and drug resistance …
Assessment of protein assembly prediction in CASP12
We present the results of the first independent assessment of protein assemblies in CASP. A
total of 1624 oligomeric models were submitted by 108 predictor groups for the 30 …
total of 1624 oligomeric models were submitted by 108 predictor groups for the 30 …
Assessment of protein assembly prediction in CASP13
We present the assembly category assessment in the 13th edition of the CASP community‐
wide experiment. For the second time, protein assemblies constitute an independent …
wide experiment. For the second time, protein assemblies constitute an independent …
Trop2 forms a stable dimer with significant structural differences within the membrane-distal region as compared to EpCAM
M Pavšič - International journal of molecular sciences, 2021 - mdpi.com
Trop2 is a cell-surface transmembrane glycoprotein involved in the maintenance of
epithelial tissue integrity and is an important carcinoma marker. It shares similar claudin …
epithelial tissue integrity and is an important carcinoma marker. It shares similar claudin …
ClusPro-DC: Dimer classification by the CLUSPRO server for protein–protein docking
Abstract ClusPro-DC (https://cluspro. bu. edu/) implements a straightforward approach to the
discrimination between crystallographic and biological dimers by docking the two subunits …
discrimination between crystallographic and biological dimers by docking the two subunits …
AHoJ: rapid, tailored search and retrieval of apo and holo protein structures for user-defined ligands
Understanding the mechanism of action of a protein or designing better ligands for it, often
requires access to a bound (holo) and an unbound (apo) state of the protein. Resources for …
requires access to a bound (holo) and an unbound (apo) state of the protein. Resources for …
Distinguishing crystallographic from biological interfaces in protein complexes: role of intermolecular contacts and energetics for classification
Background Study of macromolecular assemblies is fundamental to understand functions in
cells. X-ray crystallography is the most common technique to solve their 3D structure at …
cells. X-ray crystallography is the most common technique to solve their 3D structure at …