Lassa fever—the road ahead
RF Garry - Nature Reviews Microbiology, 2023 - nature.com
Lassa virus (LASV) is endemic in the rodent populations of Sierra Leone, Nigeria and other
countries in West Africa. Spillover to humans occurs frequently and results in Lassa fever, a …
countries in West Africa. Spillover to humans occurs frequently and results in Lassa fever, a …
Rise of the RNA machines–self-amplification in mRNA vaccine design
JDG Comes, GP Pijlman, TAH Hick - Trends in Biotechnology, 2023 - cell.com
Abstract mRNA vaccines have won the race for early COVID-19 vaccine approval, yet
improvements are necessary to retain this leading role in combating infectious diseases. A …
improvements are necessary to retain this leading role in combating infectious diseases. A …
Lassa virus glycoprotein nanoparticles elicit neutralizing antibody responses and protection
PJM Brouwer, A Antanasijevic, AJ Ronk… - Cell Host & Microbe, 2022 - cell.com
The Lassa virus is endemic in parts of West Africa, and it causes hemorrhagic fever with high
mortality. The development of a recombinant protein vaccine has been hampered by the …
mortality. The development of a recombinant protein vaccine has been hampered by the …
A recombinant VSV-vectored vaccine rapidly protects nonhuman primates against heterologous lethal Lassa fever
Lassa virus (LASV) is recognized by the World Health Organization as one of the top five
pathogens likely to cause a severe outbreak. A recent unprecedented resurgence of LASV …
pathogens likely to cause a severe outbreak. A recent unprecedented resurgence of LASV …
[HTML][HTML] Adenovirus-based vaccines—a platform for pandemic preparedness against emerging viral pathogens
L Coughlan, EJ Kremer, DM Shayakhmetov - Molecular Therapy, 2022 - cell.com
Zoonotic viruses continually pose a pandemic threat. Infection of humans with viruses for
which we typically have little or no prior immunity can result in epidemics with high morbidity …
which we typically have little or no prior immunity can result in epidemics with high morbidity …
Pathogenicity and virulence mechanisms of Lassa virus and its animal modeling, diagnostic, prophylactic, and therapeutic developments
HL Murphy, H Ly - Virulence, 2021 - Taylor & Francis
Lassa fever (LF) is a deadly viral hemorrhagic disease that is endemic to West Africa. The
causative agent of LF is Lassa virus (LASV), which causes approximately 300,000 infections …
causative agent of LF is Lassa virus (LASV), which causes approximately 300,000 infections …
[HTML][HTML] Vaccines based on the replication-deficient simian adenoviral vector ChAdOx1: Standardized template with key considerations for a risk/benefit assessment
Replication-deficient adenoviral vectors have been under investigation as a platform
technology for vaccine development for several years and have recently been successfully …
technology for vaccine development for several years and have recently been successfully …
The Arenaviridae family: knowledge gaps, animal models, countermeasures, and prototype pathogens
KM Hastie, LI Melnik, RW Cross… - The Journal of …, 2023 - academic.oup.com
Lassa virus (LASV), Junin virus (JUNV), and several other members of the Arenaviridae
family are capable of zoonotic transfer to humans and induction of severe viral hemorrhagic …
family are capable of zoonotic transfer to humans and induction of severe viral hemorrhagic …
Lessons from the pandemic: Responding to emerging zoonotic viral diseases—a Keystone Symposia report
J Cable, A Fauci, WE Dowling… - Annals of the New …, 2022 - Wiley Online Library
The COVID‐19 pandemic caught the world largely unprepared, including scientific and
policy communities. On April 10–13, 2022, researchers across academia, industry …
policy communities. On April 10–13, 2022, researchers across academia, industry …
Vaccine candidates against arenavirus infections
T Saito, RA Reyna, S Taniguchi, K Littlefield… - Vaccines, 2023 - mdpi.com
The viral family Arenaviridae contains several members that cause severe, and often lethal,
diseases in humans. Several highly pathogenic arenaviruses are classified as Risk Group 4 …
diseases in humans. Several highly pathogenic arenaviruses are classified as Risk Group 4 …