Organoid systems leverage the self-organizing properties of stem cells to create diverse
multi-cellular tissue proxies. Most organoid models only represent single or partial …

Stem cell–based approaches have received much hype as potential treatments for
neurodegenerative disorders. Indeed, transplantation of stem cells or their derivatives in …

The mammalian nervous system comprises many distinct neuronal subtypes, each with its
own phenotype and differential sensitivity to degenerative disease. Although specific …

Motoneurons represent a specialized class of neurons essential for the control of body
movement. Motoneuron loss is the cause of a wide range of neurological disorders including …

Embryogenesis is a highly regulated process in which the precise spatial and temporal
release of soluble cues directs differentiation of multipotent stem cells into discrete …

All muscle movements, including breathing, walking, and fine motor skills rely on the
function of the spinal motor neuron to transmit signals from the brain to individual muscle …

The formation of locomotor circuits depends on the spatially organized generation of motor
columns that innervate distinct muscle and autonomic nervous system targets along the …

Although great progress has been made in the isolation and culture of stem cells, the future
of stem-cell-based therapies and their productive use in drug discovery and regenerative …

Cultured ESCs can form different classes of neurons, but whether these neurons can
acquire specialized subtype features typical of neurons in vivo remains unclear. We show …

A key objective of stem cell biology is to create physiologically relevant cells suitable for
modeling disease pathologies in vitro. Much progress towards this goal has been made in …