This digest covers some of the most relevant progress in malaria drug discovery published
between 2010 and 2012. There is an urgent need to develop new antimalarial drugs. Such …

The growing demand to fulfill the needs of present-day medicine in terms of novel effective
molecules has lead to reexamining some of the old and known bacterial secondary …

Inflammation, oxidation, and compromised immunity all increase the dangers of COVID-19,
whereas many pharmaceutical protocols may lead to increased immunity such as ingesting …

In this study, a series of thiazolidine-2, 4-dione derivatives 3a–i were synthesized and
evaluated for antibacterial activity against Gram-positive and Gram-negative strains of …

Pyrroles and their fused compounds are widely known as biologically active scaffolds, which
are mainly fused at the 1–2 (a), 2–3 (b), 3–4 (c) and 4–5 (d) positions. In pyrrole ring …

Abstract Quantitative Structure–Activity Relationship not only provides guidelines regarding
structural features responsible for biological activity but it can be used also for prediction of …

Psoralen or furocoumarin is a linear three ring heterocyclic compound. Psoralens are
planar, tricyclic compounds, consisting of a furan ring fused to a coumarin moiety. Psoralen …

A series of novel carbonyl compounds was synthesized by a simple, eco-friendly and
efficient method. These compounds were screened for anti-oxidant activity, in vitro …

Despite recent developments in combinatorial chemistry and related techniques for
facilitating drug discovery and development, natural products continue to play a prominent …

In the present work, sixty substituted 2-Phenylimidazopyridines previously reported with
potent anti-human African trypanosomiasis (HAT) activity were selected to build genetic …