The nuclear enzymes called poly (ADP-ribose) polymerases (PARPs) are known to catalyze
the process of PARylation, which plays a vital role in various cellular functions. They have …

Tumors with BRCA1/2 mutations or homologous recombination repair defects are sensitive
to PARP inhibitors through the mechanism of synthetic lethality. Several PARP inhibitors are …

The enhancer of zeste homolog 2 (EZH2) protein is the catalytic subunit of one of the histone
methyltransferases. EZH2 catalyzes the trimethylation of lysine 27 of histone H3 …

Simple Summary Epigenetic changes in a cell's genome can cause the inactivation of genes
and affect how tumours respond to chemotherapy. These epigenetic changes do not alter …

Breast and ovarian cancers pose significant therapeutic challenges. We explored the
synergistic cytotoxicity of histone deacetylase inhibitors (HDACis), poly (ADP-ribose) …

The principal understanding of the Poly (ADP-ribose) polymerase (PARP) regulation of
genomes has been focused on its role in DNA repair; however, in the past few years, an …

Abstract Cyclin-dependent kinase 4/6 (CDK4/6) acts as a crucial point of regulation in the G1-
to-S transition in the cell division cycle, its aberrant activation was found in various human …