Nuclear receptor subfamily 1, group D, member 1 (NR1D1, also known as REV-ERBα)
belongs to the nuclear receptor (NR) family, and is a heme-binding component of the …

Abstract Purpose of Review Over the last years, we have learned that the metabolic
phenotype of immune cells is closely connected to the cell's effector function. Understanding …

Circadian rhythms and sex differences are involved in the pathophysiology of asthma. Yet,
there are no reports that simultaneously address the role of the circadian clock and sex …

Background An increasing number of clinical studies have begun to explore combination
strategies with immune checkpoint inhibitors, aiming to present new opportunities for …

Ovarian cancer (OVC) is one of the most common causes of cancer-related deaths in
women worldwide. Despite advancements in detection and therapy, the prognosis of OVC …

Parkinson's disease is a progressive neurodegenerative disease that affects the motor and
non-motor circuits of the brain. Currently, there are no promising therapeutic measures for …

The regulation of RBC homeostasis by erythropoietin (EPO) is critical for O2 transport and
maintaining the adequate number of RBCs in vertebrates. Therefore, dysregulation in EPO …

Allergic contact dermatitis (ACD) is the most common chronic inflammatory skin disease (or
immune-mediated disease), causing disruption to our psychological condition and life …

Asthma demonstrates a strong circadian rhythm with disrupted molecular clock. Melatonin
which can directly regulate circadian rhythm has been reported to alleviate asthma, but …

Asthma is a common chronic respiratory disease characterized by Th2-type inflammation in
the airways. Leucine zip transcription factor-like 1 (LZTFL1) has been implicated in the …