Integrator: surprisingly diverse functions in gene expression
The discovery of the metazoan-specific Integrator (INT) complex represented a breakthrough
in our understanding of noncoding U-rich small nuclear RNA (UsnRNA) maturation and has …
in our understanding of noncoding U-rich small nuclear RNA (UsnRNA) maturation and has …
Biogenesis of multisubunit RNA polymerases
T Wild, P Cramer - Trends in biochemical sciences, 2012 - cell.com
Gene transcription in the nucleus of eukaryotic cells is carried out by three related
multisubunit RNA polymerases, Pol I, Pol II and Pol III. Although the structure and function of …
multisubunit RNA polymerases, Pol I, Pol II and Pol III. Although the structure and function of …
Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer
C Lesseur, B Diergaarde, AF Olshan, V Wünsch-Filho… - Nature …, 2016 - nature.com
We conducted a genome-wide association study of oral cavity and pharyngeal cancer in
6,034 cases and 6,585 controls from Europe, North America and South America. We …
6,034 cases and 6,585 controls from Europe, North America and South America. We …
[HTML][HTML] DIP-MS: ultra-deep interaction proteomics for the deconvolution of protein complexes
Most proteins are organized in macromolecular assemblies, which represent key functional
units regulating and catalyzing most cellular processes. Affinity purification of the protein of …
units regulating and catalyzing most cellular processes. Affinity purification of the protein of …
[HTML][HTML] Guanosine triphosphate links MYC-dependent metabolic and ribosome programs in small-cell lung cancer
MYC stimulates both metabolism and protein synthesis, but how cells coordinate these
complementary programs is unknown. Previous work reported that, in a subset of small-cell …
complementary programs is unknown. Previous work reported that, in a subset of small-cell …
[HTML][HTML] RNA Pol II length and disorder enable cooperative scaling of transcriptional bursting
Summary RNA polymerase II (RNA Pol II) contains a disordered C-terminal domain (CTD)
whose length enigmatically correlates with genome size. The CTD is crucial to eukaryotic …
whose length enigmatically correlates with genome size. The CTD is crucial to eukaryotic …
tRNA 2′-O-methylation by a duo of TRM7/FTSJ1 proteins modulates small RNA silencing in Drosophila
MT Angelova, DG Dimitrova, B Da Silva… - Nucleic Acids …, 2020 - academic.oup.com
O-Methylation (Nm) represents one of the most common RNA modifications. Nm affects RNA
structure and function with crucial roles in various RNA-mediated processes ranging from …
structure and function with crucial roles in various RNA-mediated processes ranging from …
[HTML][HTML] The prefoldin bud27 mediates the assembly of the eukaryotic RNA polymerases in an rpb5-dependent manner
MC Mirón-García, AI Garrido-Godino… - PLoS …, 2013 - journals.plos.org
The unconventional prefoldin URI/RMP, in humans, and its orthologue in yeast, Bud27, have
been proposed to participate in the biogenesis of the RNA polymerases. However, this role …
been proposed to participate in the biogenesis of the RNA polymerases. However, this role …
[HTML][HTML] Global control of RNA polymerase II
A Gillis, S Berry - Biochimica et Biophysica Acta (BBA)-Gene Regulatory …, 2024 - Elsevier
Abstract RNA polymerase II (Pol II) is the multi-protein complex responsible for transcribing
all protein-coding messenger RNA (mRNA). Most research on gene regulation is focused on …
all protein-coding messenger RNA (mRNA). Most research on gene regulation is focused on …
Xpo7 is a broad-spectrum exportin and a nuclear import receptor
Exportins bind cargo molecules in a RanGTP-dependent manner inside nuclei and transport
them through nuclear pores to the cytoplasm. CRM1/Xpo1 is the best-characterized exportin …
them through nuclear pores to the cytoplasm. CRM1/Xpo1 is the best-characterized exportin …