蛋白质与线性DNA 片断结合过程中的末端效应

杨晓静, 刘曦励, 娄春波, 欧阳颀 - 物理化学学报, 2010 - whxb.pku.edu.cn
各种体外实验技术被广泛地用来研究DNA-蛋白质之间的相互作用, 但体外和体内实验一个最
明显的区别是实验使用的DNA 片段远远短于基因组DNA, 因而多出了大量线性DNA 分子末端 …

Estimation of statistical binding properties of ligand population during in vitro selection based on population dynamics theory

T Aita, K Nishigaki, Y Husimi - Mathematical biosciences, 2014 - Elsevier
During in vitro selection process, it is very valuable to monitor the binding properties of the
ligand population in real time, particularly the population average of the association constant …

Biomolecular Information Gained through In Vitro Evolution on a Fitness Landscape in Sequence Space

T Aita, Y Husimi - Recent Advances in the Theory and Application of …, 2014 - Springer
Biological evolution at the molecular level is conceptually regarded as the genetic
information gaining process. Analyzing the in vitro evolution process, which is a simplified …

End Effects during the Binding of Protein to Linear DNA Fragments

XJ YANG, XL LIU, CB LOU… - Acta Physico-Chimica …, 2010 - ingentaconnect.com
Many in vitro techniques have been employed to elucidate the interaction between DNA and
protein. However, one of the most significant differences between in vitro and in vivo studies …