Advances in hydrogel technology have unlocked unique and valuable capabilities that are
being applied to a diverse set of translational applications. Hydrogels perform functions …

Abstract The 2018 Nobel Prize in Physiology or Medicine was awarded to pioneers in the
field of cancer immunotherapy, as the utility of leveraging a patient's coordinated and …

Cytokines are immunoregulatory proteins involved in many pathological states with
promising potential as therapeutic agents. A diverse array of cytokines has been studied in …

Effective antitumor immunity in mice requires activation of the type I interferon (IFN)
response pathway. IFNα and IFNβ therapies have proven promising in humans, but suffer …

The incidence of cancer is increasing year by year. Cancer has become one of the health
threats of modern people. Simply relying on the surgery, chemotherapy or radiotherapy, not …

Cytokines have long been considered promising cancer immunotherapy agents due to their
endogenous role in activating and proliferating lymphocytes. However, since the initial FDA …

Purpose: Men with metastatic castration-resistant prostate cancer (mCRPC) have limited
treatment options after progressing on hormonal therapy and chemotherapy. Here, we …

A plethora of new cancer immunotherapies are under clinical development individually and
in combination for a wide variety of indications, but optimizing therapeutic outcomes will …

Introduction On-target, off-tumor toxicity severely limits systemic dosing of cytokines and
agonist antibodies for cancer. Intratumoral administration is increasingly being explored to …

Background Preclinical research suggests that the efficacy of immune checkpoint inhibitors
in breast cancer can be enhanced by combining them with antiangiogenics, particularly in a …