Herpes simplex virus type 1 (HSV) keratitis is a leading cause of infectious blindness.
Clinical disease occurs variably throughout the cornea from epithelium to endothelium and …

Heparan sulfate (HS) is ubiquitously expressed on mammalian cells. It is a polysaccharide
that binds growth factors, cytokines, and chemokines, and thereby controls several important …

Summary Herpes simplex virus-1 (HSV-1) causes lifelong recurrent pathologies without a
cure. How infection by HSV-1 triggers disease processes, especially in the immune …

Herpes simplex virus type 1 (HSV-1) causes recurrent mucocutaneous lesions in the eye
that may advance to corneal blindness. Nucleoside analogs exemplified by acyclovir (ACV) …

Herpes simplex virus type 1 (HSV-1) is an important factor for vision loss in developed
countries. A challenging aspect of the ocular infection by HSV-1 is that common treatments …

Heparan sulfate is a glycosaminoglycan present in nearly all mammalian tissues. Heparan
sulfate moieties are attached to the cell surface via heparan sulfate proteoglycans (HSPGs) …

Tissue-resident memory T cells (TRM) were first described in 2009. While initially the major
focus was on CD8+ TRM, there has recently been increased interest in defining the …

Ocular herpes simplex type 1 (HSV-1) infections can trigger conjunctivitis, keratitis, uveitis,
and occasionally retinitis, and is a major cause of blindness worldwide. The infections are …

Herpesviruses are ubiquitous human pathogens that tightly regulate many cellular pathways
including the unfolded protein response to endoplasmic reticulum (ER) stress …

Ocular herpesviruses, most notably human alphaherpesvirus 1 (HSV-1), canid
alphaherpesvirus 1 (CHV-1) and felid alphaherpesvirus 1 (FHV-1), infect and cause severe …