Exploiting the biogenesis of extracellular vesicles for bioengineering and therapeutic cargo loading

J Rädler, D Gupta, A Zickler, SEL Andaloussi - Molecular Therapy, 2023 - cell.com
Extracellular vesicles (EVs) are gaining increasing attention for diagnostic and therapeutic
applications in various diseases. These natural nanoparticles benefit from favorable safety …

Shedding light on extracellular vesicle biogenesis and bioengineering

F Teng, M Fussenegger - Advanced Science, 2021 - Wiley Online Library
Extracellular vesicles (EVs) are biocompatible, nano‐sized secreted vesicles containing
many types of biomolecules, including proteins, RNAs, DNAs, lipids, and metabolites. Their …

Inhibiting extracellular vesicles formation and release: a review of EV inhibitors

M Catalano, L O'Driscoll - Journal of extracellular vesicles, 2020 - Taylor & Francis
It is now becoming well established that vesicles are released from a broad range of cell
types and are involved in cell-to-cell communication, both in physiological and pathological …

Extracellular vesicles: unique intercellular delivery vehicles

SLN Maas, XO Breakefield, AM Weaver - Trends in cell biology, 2017 - cell.com
Extracellular vesicles (EVs) are a heterogeneous collection of membrane-bound carriers
with complex cargoes including proteins, lipids, and nucleic acids. While the release of EVs …

Extracellular vesicles in angiogenesis

D Todorova, S Simoncini, R Lacroix, F Sabatier… - Circulation …, 2017 - Am Heart Assoc
During the past decade, extracellular vesicles (EVs), which include apoptotic bodies,
microvesicles, and exosomes, have emerged as important players in cell-to-cell …

Monocytes and macrophages in tissue repair: Implications for immunoregenerative biomaterial design

ME Ogle, CE Segar, S Sridhar… - … Biology and Medicine, 2016 - journals.sagepub.com
Monocytes and macrophages play a critical role in tissue development, homeostasis, and
injury repair. These innate immune cells participate in guiding vascular remodeling …

Recent advances in the treatment of sickle cell disease

G Salinas Cisneros, SL Thein - Frontiers in physiology, 2020 - frontiersin.org
Sickle cell anemia (SCA) was first described in the Western literature more than 100 years
ago. Elucidation of its molecular basis prompted numerous biochemical and genetic studies …

Inflammation in sickle cell disease

N Conran, JD Belcher - Clinical hemorheology and …, 2018 - content.iospress.com
The primary β-globin gene mutation that causes sickle cell disease (SCD) has significant
pathophysiological consequences that result in hemolytic events and the induction of the …

Microvesicles in vascular homeostasis and diseases

VC Ridger, CM Boulanger… - Thrombosis and …, 2017 - thieme-connect.com
Microvesicles are members of the family of extracellular vesicles shed from the plasma
membrane of activated or apoptotic cells. Microvesicles were initially characterised by their …

Role of sphingolipids in the biogenesis and biological activity of extracellular vesicles

C Verderio, M Gabrielli, P Giussani - Journal of lipid research, 2018 - ASBMB
Extracellular vesicles (EVs) are membrane vesicles released by both eukaryotic and
prokaryotic cells; they not only serve physiological functions, such as disposal of cellular …