Alcohol and the brain: neuronal molecular targets, synapses, and circuits

KP Abrahao, AG Salinas, DM Lovinger - Neuron, 2017 - cell.com
Ethanol is one of the most commonly abused drugs. Although environmental and genetic
factors contribute to the etiology of alcohol use disorders, it is ethanol's actions in the brain …

Synaptic targets: Chronic alcohol actions

M Roberto, FP Varodayan - Neuropharmacology, 2017 - Elsevier
Alcohol acts on numerous cellular and molecular targets to regulate neuronal
communication within the brain. Chronic alcohol exposure and acute withdrawal generate …

Brain ethanol metabolism by astrocytic ALDH2 drives the behavioural effects of ethanol intoxication

S Jin, Q Cao, F Yang, H Zhu, S Xu, Q Chen, Z Wang… - Nature …, 2021 - nature.com
Alcohol is among the most widely used psychoactive substances worldwide. Ethanol
metabolites such as acetate, thought to be primarily the result of ethanol breakdown by …

Alcohol use disorder: neurobiology and therapeutics

W Yang, R Singla, O Maheshwari, CJ Fontaine… - Biomedicines, 2022 - mdpi.com
Alcohol use disorder (AUD) encompasses the dysregulation of multiple brain circuits
involved in executive function leading to excessive consumption of alcohol, despite negative …

Synaptic effects induced by alcohol

DM Lovinger, M Roberto - 2023 - Springer
Ethanol (EtOH) has effects on numerous cellular molecular targets, and alterations in
synaptic function are prominent among these effects. Acute exposure to EtOH activates or …

Neurobiology of alcohol seeking behavior

E Domi, A Domi, L Adermark, M Heilig… - Journal of …, 2021 - Wiley Online Library
Alcohol addiction is a chronic relapsing brain disease characterized by an impaired ability to
stop or control alcohol use despite adverse consequences. A main challenge of addiction …

GABAergic signaling in alcohol use disorder and withdrawal: pathological involvement and therapeutic potential

RN Dharavath, C Pina-Leblanc, VM Tang… - Frontiers in Neural …, 2023 - frontiersin.org
Alcohol is one of the most widely used substances. Alcohol use accounts for 5.1% of the
global disease burden, contributes substantially to societal and economic costs, and leads …

Mechanisms of ethanol-induced cerebellar ataxia: underpinnings of neuronal death in the cerebellum

H Mitoma, M Manto, AG Shaikh - International journal of environmental …, 2021 - mdpi.com
Ethanol consumption remains a major concern at a world scale in terms of transient or
irreversible neurological consequences, with motor, cognitive, or social consequences …

Effects of ethanol on the cerebellum: advances and prospects

J Luo - The Cerebellum, 2015 - Springer
Alcohol abuse causes cerebellar dysfunction and cerebellar ataxia is a common feature in
alcoholics. Alcohol exposure during development also impacts the cerebellum. Children …

Effects of fluoride long-term exposure over the cerebellum: global proteomic profile, oxidative biochemistry, cell density, and motor behavior evaluation

GO Lopes, MK Martins Ferreira, L Davis… - International journal of …, 2020 - mdpi.com
Although the literature does not provide evidence of health risks from exposure to fluoride
(F) in therapeutic doses, questions remain about the effects of long-term and high-dose use …