Currently, two main cell culture models predominate pluripotent stem cell research:
embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). Thanks to their …

After fertilization, the quiescent zygote experiences a burst of genome activation that initiates
a short-lived totipotent state. Understanding the process of totipotency in human cells would …

Embryonic stem cells (ESCs) are derived from the pre-implantation mammalian blastocyst.
At this point in time, the newly formed embryo is concerned with the generation and …

Abstract DNA methylation (5-methylcytosine (5mC)) is critical for genome stability and
transcriptional regulation in mammals. The discovery that ten-eleven translocation (TET) …

Totipotent cells hold enormous potential for regenerative medicine. Thus, the development
of cellular models recapitulating totipotent-like features is of paramount importance. Cells …

Lactate was recently found to mediate histone lysine lactylation and facilitate polarization of
M1 macrophages, indicating its role in metabolic regulation of gene expression. During …

Membrane-less organelles are condensates formed by phase separation whose functions
often remain enigmatic. Upon oxidative stress, PML scaffolds Nuclear Bodies (NBs) to …

Translational control is critical for cell fate transitions during development, lineage
specification, and tumorigenesis. Here, we show that the transcription factor double …

The cellular microenvironment, together with intrinsic regulators, shapes stem cell identity
and differentiation capacity. Mammalian early embryos are exposed to hypoxia in vivo and …

Multicellular organisms develop from a single cell, the zygote. This feature is referred to as
totipotency. In the mouse, only the zygote and the 2-cell stage embryo display this attribute …