Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences
N Exner, AK Lutz, C Haass, KF Winklhofer - The EMBO journal, 2012 - embopress.org
Neurons are critically dependent on mitochondrial integrity based on specific morphological,
biochemical, and physiological features. They are characterized by high rates of metabolic …
biochemical, and physiological features. They are characterized by high rates of metabolic …
The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease
MR Cookson - Nature Reviews Neuroscience, 2010 - nature.com
Parkinson's disease, like many common age-related conditions, is now recognized to have a
substantial genetic component. Here, I discuss how mutations in a large complex gene …
substantial genetic component. Here, I discuss how mutations in a large complex gene …
Structural analysis of the full-length human LRRK2
Mutations in leucine-rich repeat kinase 2 (LRRK2) are commonly implicated in the
pathogenesis of both familial and sporadic Parkinson's disease (PD). LRRK2 regulates …
pathogenesis of both familial and sporadic Parkinson's disease (PD). LRRK2 regulates …
LRRK2 phosphorylates membrane-bound Rabs and is activated by GTP-bound Rab7L1 to promote recruitment to the trans-Golgi network
Human genetic studies implicate LRRK2 and RAB7L1 in susceptibility to Parkinson disease
(PD). These two genes function in the same pathway, as knockout of Rab7L1 results in …
(PD). These two genes function in the same pathway, as knockout of Rab7L1 results in …
Ser1292 Autophosphorylation Is an Indicator of LRRK2 Kinase Activity and Contributes to the Cellular Effects of PD Mutations
Z Sheng, S Zhang, D Bustos, T Kleinheinz… - Science translational …, 2012 - science.org
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common cause of
familial Parkinson's disease (PD). Although biochemical studies have shown that certain PD …
familial Parkinson's disease (PD). Although biochemical studies have shown that certain PD …
Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser910/Ser935, disruption of 14-3-3 binding and altered cytoplasmic localization
LRRK2 (leucine-rich repeat protein kinase 2) is mutated in a significant number of
Parkinson's disease patients. Since a common mutation that replaces Gly2019 with a serine …
Parkinson's disease patients. Since a common mutation that replaces Gly2019 with a serine …
Cellular processes associated with LRRK 2 function and dysfunction
R Wallings, C Manzoni, R Bandopadhyay - The FEBS journal, 2015 - Wiley Online Library
Mutations in the leucine‐rich repeat kinase 2 (LRRK 2)‐encoding gene are the most
common cause of monogenic Parkinson's disease. The identification of LRRK 2 …
common cause of monogenic Parkinson's disease. The identification of LRRK 2 …
Pathological functions of LRRK2 in Parkinson's disease
GR Jeong, BD Lee - Cells, 2020 - mdpi.com
Mutations in the gene encoding leucine-rich repeat kinase 2 (LRRK2) are common genetic
risk factors for both familial and sporadic Parkinson's disease (PD). Pathogenic mutations in …
risk factors for both familial and sporadic Parkinson's disease (PD). Pathogenic mutations in …
Structural model of the dimeric Parkinson's protein LRRK2 reveals a compact architecture involving distant interdomain contacts
Leucine-rich repeat kinase 2 (LRRK2) is a large, multidomain protein containing two
catalytic domains: a Ras of complex proteins (Roc) G-domain and a kinase domain …
catalytic domains: a Ras of complex proteins (Roc) G-domain and a kinase domain …
Human iPSC-derived microglia carrying the LRRK2-G2019S mutation show a Parkinson's disease related transcriptional profile and function
S Ohtonen, L Giudice, H Jäntti, MF Fazaludeen… - Scientific Reports, 2023 - nature.com
Abstract LRRK2-G2019S is one of the most common Parkinson's disease (PD)-associated
mutations and has been shown to alter microglial functionality. However, the impact of …
mutations and has been shown to alter microglial functionality. However, the impact of …