Tobacco smoking is a major determinant of preventable morbidity and mortality worldwide.
More than a billion people smoke, and without major increases in cessation, at least half will …

Neuronal nicotinic acetylcholine receptors (nAChRs) regulate the rewarding actions of
nicotine contained in tobacco that establish and maintain the smoking habit. nAChRs also …

Nicotine is a highly addictive drug found in tobacco that drives its continued use despite the
harmful consequences. The initiation of nicotine abuse involves the mesolimbic dopamine …

• Genetic and environmental influences modulating risk of substance use disorders change
developmentally and across the lifespan.• Genes involved in vulnerability to addictions …

Tobacco smoking results in more than five million deaths each year and accounts for∼ 90%
of all deaths from lung cancer. Nicotine, the major reinforcing component of tobacco smoke …

Tobacco smoking results in more than 5 million deaths each year and accounts for almost
90% of all deaths from lung cancer. Nicotine, the major reinforcing component of tobacco …

Addictions are heritable and unfold dynamically across the lifespan. One prominent
neurobiological theory proposes that substance-induced changes in neural circuitry promote …

Nicotine stimulates brain reward circuitries, most prominently the mesocorticolimbic
dopamine system, and this action plays a critical in establishing and maintaining the tobacco …

Background Two single-nucleotide polymorphisms, rs1051730 and rs16969968, located
within the nicotinic acetylcholine receptor gene cluster on chromosome 15q25 locus, are …

Nicotine dependence risk and lung cancer risk are associated with variants in a region of
chromosome 15 encompassing genes encoding the nicotinic receptor subunits CHRNA5 …