Modern viral kinetic modeling and its application to therapeutics is a field that attracted the
attention of the medical, pharmaceutical, and modeling communities during the early days of …

HIV-1 eradication from infected individuals has not been achieved with the prolonged use of
highly active antiretroviral therapy (HAART). The cellular reservoir for HIV-1 in resting …

To affect the COVID-19 pandemic, lifesaving antiviral therapies must be identified. The
number of clinical trials that can be performed is limited. We developed mathematical …

Although potent combination therapy is usually able to suppress plasma viral loads in HIV-1
patients to below the detection limit of conventional clinical assays, a low level of viremia …

Most infants born to human immunodeficiency virus (HIV)‐infected women escape HIV
infection. Infants evade infection despite an immature immune system and, in the case of …

Influenza virus infections are a leading cause of morbidity and mortality worldwide. This is
due in part to the continual emergence of new viral variants and to synergistic interactions …

When antiretroviral therapy (ART) is administered for long periods to HIV-1-infected patients,
most achieve viral loads that are “undetectable” by standard assay methods (ie, HIV-1 RNA< …

Most HIV-infected patients when treated with combination antiretroviral therapy achieve viral
loads that are below the current limit of detection of standard assays after a few months …

Mathematical models that describe infection kinetics help elucidate the time scales,
effectiveness, and mechanisms underlying viral growth and infection resolution. For …

Recent efforts to cure human immunodeficiency virus type-1 (HIV-1) infection have focused
on developing latency reversing agents as a first step to eradicate the latent reservoir. The …