Progress and pitfalls of gene editing technology in CAR-T cell therapy: a state-of-the-art review

V Moradi, E Khodabandehloo, M Alidadi… - Frontiers in …, 2024 - pmc.ncbi.nlm.nih.gov
CAR-T cell therapy has shown remarkable promise in treating B-cell malignancies, which
has sparked optimism about its potential to treat other types of cancer as well. Nevertheless …

Advancements in Cell-Based Therapies for HIV Cure

Y Matsui, Y Miura - Cells, 2023 - mdpi.com
The treatment of human immunodeficiency virus (HIV-1) has evolved since the
establishment of combination antiretroviral therapy (ART) in the 1990s, providing HIV …

Unedited allogeneic iNKT cells show extended persistence in MHC-mismatched canine recipients

A Rotolo, EC Whelan, MJ Atherton, I Kulikovskaya… - Cell Reports …, 2023 - cell.com
Allogeneic invariant natural killer T cells (allo-iNKTs) induce clinical remission in patients
with otherwise incurable cancers and COVID-19-related acute respiratory failure. However …

Bacterial immunotherapy: is it a weapon in our arsenal in the fight against cancer?

S Sharma, H Sharma, H Gogoi - Frontiers in Immunology, 2023 - frontiersin.org
Advances in understanding the genetic basis of cancer have driven alternative treatment
approaches. Recent findings have demonstrated the potential of bacteria and it's …

The future of CAR T therapeutics to treat autoimmune disorders

AC Pecher, L Hensen, C Lengerke, J Henes - Molecular Diagnosis & …, 2024 - Springer
The concept of chimeric antigen receptor (CAR) T cell therapy emerged from cancer
immunotherapy and has been rapidly adapted and developed for the treatment of …

Current advancements in cellular immunotherapy for autoimmune disease

CT Berry, CS Frazee, PJ Herman, S Chen… - Seminars in …, 2025 - Springer
The management of autoimmune diseases is currently limited by therapies that largely
suppress the immune system, often resulting in partial and temporary remissions. Cellular …

Finding your CAR: The road ahead for engineered T-cells

PH Chen, R Raghunandan, JS Morrow… - The American Journal of …, 2024 - Elsevier
Adoptive cellular therapy using chimeric antigen receptors (CAR) has transformed
immunotherapy by engineering T cells to target specific antigens on tumor cells. As the field …

Lentiviral vector determinants of anion‐exchange chromatography elution heterogeneity

G Pamenter, L Davies, C Lamont… - Biotechnology and …, 2024 - Wiley Online Library
Abstract The demand for Lentiviral Vector (LV) drug substance is increasing. However,
primary capture using convective anion‐exchange chromatography remains a significant …

[HTML][HTML] Advances in CAR-NK cell therapy for lung cancer: is it a better choice in the future?

F Liu, X Miao, L Han, X Song - Frontiers in Oncology, 2024 - ncbi.nlm.nih.gov
Lung cancer remains one of the leading causes of cancer-related mortality worldwide
necessitating the development of innovative therapeutic strategies. Chimeric antigen …

Mitigating time toxicity in lymphoma and multiple myeloma

M Di, CT Su, AJ Cowan, AK Gopal… - Leukemia & …, 2024 - Taylor & Francis
The concept of time toxicity in oncology refers to the presence of frequent healthcare-related
interactions that can interfere with patient well-being. In this review, we examine several …