Kratom—pharmacology, clinical implications, and outlook: a comprehensive review

SC Eastlack, EM Cornett, AD Kaye - Pain and therapy, 2020 - Springer
Kratom, or Mitragyna, is a tropical plant indigenous to Southeast Asia, with unique
pharmacological properties. It is commonly consumed by preparing the leaves into …

From Kratom to mitragynine and its derivatives: physiological and behavioural effects related to use, abuse, and addiction

Z Hassan, M Muzaimi, V Navaratnam… - Neuroscience & …, 2013 - Elsevier
Kratom (or Ketum) is a psychoactive plant preparation used in Southeast Asia. It is derived
from the plant Mitragyna speciosa Korth. Kratom as well as its main alkaloid, mitragynine …

Following “the Roots” of Kratom (Mitragyna speciosa): The Evolution of an Enhancer from a Traditional Use to Increase Work and Productivity in Southeast Asia to a …

E Cinosi, G Martinotti, P Simonato… - BioMed research …, 2015 - Wiley Online Library
The use of substances to enhance human abilities is a constant and cross‐cultural feature in
the evolution of humanity. Although much has changed over time, the availability on the …

Pharmacology of kratom: an emerging botanical agent with stimulant, analgesic and opioid-like effects

WC Prozialeck, JK Jivan, SV Andurkar - Journal of Osteopathic …, 2012 - degruyter.com
Kratom (Mitragyna speciosa) is a plant indigenous to Thailand and Southeast Asia. Kratom
leaves produce complex stimulant and opioid-like analgesic effects. In Asia, kratom has …

[HTML][HTML] Kratom policy: the challenge of balancing therapeutic potential with public safety

WC Prozialeck, BA Avery, EW Boyer… - International Journal of …, 2019 - Elsevier
Kratom (Mitragyna speciosa) is a tree-like plant indigenous to Southeast Asia. Its leaves,
and the teas brewed from them have long been used by people in that region to stave off …

Abuse potential and adverse cognitive effects of mitragynine (kratom)

NHM Yusoff, FW Suhaimi, RK Vadivelu… - Addiction …, 2016 - Wiley Online Library
Mitragynine is the major psychoactive alkaloid of the plant kratom/ketum. Kratom is widely
used in S outheast A sia as a recreational drug, and increasingly appears as a pure …

A botanical, phytochemical and ethnomedicinal review of the genus Mitragyna korth: Implications for products sold as kratom

PN Brown, JA Lund, SJ Murch - Journal of Ethnopharmacology, 2017 - Elsevier
Abstract Ethnopharmacological relevance The genus Mitragyna (Rubiacaeae) has been
traditionally used in parts of Africa, Asia and Oceania. In recent years, there has been …

Suspected adulteration of commercial kratom products with 7-hydroxymitragynine

AG Lydecker, A Sharma, CR McCurdy… - Journal of Medical …, 2016 - Springer
Abstract Introduction Kratom (Mitragyna speciosa), a plant native to Southeast Asia, has
been used for centuries for its stimulant and opium-like effects. Mitragynine and 7 …

Mitragynine attenuates morphine withdrawal effects in rats—a comparison with methadone and buprenorphine

R Hassan, C Pike See, S Sreenivasan… - Frontiers in …, 2020 - frontiersin.org
Background Opiate addiction is a major health problem in many countries. A crucial
component of the medical treatment is the management of highly aversive opiate withdrawal …

Analgesic effects of main indole alkaloid of kratom, mitragynine in acute pain animal model

NH Mat, SNS Bakar, V Murugaiyah… - Behavioural Brain …, 2023 - Elsevier
Mitragynine exerts its analgesic effect mainly via opioid receptors activation. Additionally, the
effect may be mediated via mitragynine's anti-inflammatory property and non-opioid receptor …