Ki-67 protein has been widely used as a proliferation marker for human tumor cells for
decades. In recent studies, multiple molecular functions of this large protein have become …

The Aurora kinase A (AURKA) is involved in different aspects of mitotic control, from mitotic
entry to cytokinesis. Consistent with its pleiotropic roles, several AURKA interactors are able …

Intracellular accumulation of wild-type tau is a hallmark of sporadic Alzheimer's disease
(AD), but the molecular mechanisms underlying tau-induced synapse impairment and …

Over four decades ago, in vitro experiments showed that tau protein interacts with and
stabilizes microtubules in a phosphorylation-dependent manner. This observation fueled the …

The etiology of Tauopathies, a diverse class of neurodegenerative diseases associated with
the Microtubule Associated Protein (MAP) Tau, is usually described by a common …

Altered protein phosphorylation states of several proteins are closely associated with
Alzheimer's disease (AD). Among these are the amyloid-β protein precursor (AβPP) and the …

The c-MYC (MYC) oncoprotein is deregulated in over 50% of cancers, yet regulatory
mechanisms controlling MYC remain unclear. To this end, we interrogated the MYC …

Simple Summary Recently, a group of genes called “Hippo” has been discovered that is
critical for the development and progression of a wide types of cancers. Therefore …

Cancer cells depend on a supportive niche (the tumor microenvironment) that promotes
tumor cell survival while protecting the malignant cells from therapeutic challenges and the …

The NF-κB signaling network, which is an ancient signaling pathway, plays a pivotal role in
innate immunity and constitutes a first line of defense against invading pathogens, including …