Post-translational modifications (PTMs) on tau have long been recognized as affecting
protein function and contributing to neurodegeneration. The explosion of information on …

Histone methylation can occur at various sites in histone proteins, primarily on lysine and
arginine residues, and it can be governed by multiple positive and negative regulators, even …

Protein lysine methylation is a crucial post-translational modification that regulates the
functions of both histone and non-histone proteins. Deregulation of the enzymes or 'writers' …

Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

Post-translational methylation plays a crucial role in regulating and optimizing protein
function. Protein histidine methylation, occurring as the two isomers 1-and 3-methylhistidine …

Many proteins are modified by posttranslational methylation, introduced by a number of
methyltransferases (MTases). Protein methylation plays important roles in modulating …

The retinoblastoma protein (pRb) functions as a cell cycle regulator controlling G1 to S
phase transition and plays critical roles in tumour suppression. It is frequently inactivated in …

Protein lysine methylation is a critical and dynamic post-translational modification that can
regulate protein stability and function. This post-translational modification is regulated by …

Protein histidine methylation is a rare post-translational modification of unknown
biochemical importance. In vertebrates, only a few methylhistidine-containing proteins have …

Eukaryotic elongation factor 1 alpha (eEF1A) delivers aminoacyl-tRNA to the ribosome and
thereby plays a key role in protein synthesis. Human eEF1A is subject to extensive post …