Microtubule dynamic instability: a new model with coupled GTP hydrolysis and multistep catastrophe
A key question in understanding microtubule dynamics is how GTP hydrolysis leads to
catastrophe, the switch from slow growth to rapid shrinkage. We first provide a review of the …
catastrophe, the switch from slow growth to rapid shrinkage. We first provide a review of the …
Toward the virtual cell: automated approaches to building models of subcellular organization “learned” from microscopy images
We review state‐of‐the‐art computational methods for constructing, from image data,
generative statistical models of cellular and nuclear shapes and the arrangement of …
generative statistical models of cellular and nuclear shapes and the arrangement of …
Towards cytoskeleton computers. A proposal
A Adamatzky, J Tuszynski, J Pieper… - From parallel to …, 2019 - taylorfrancis.com
Actin and tubulin are key structural elements of Eukaryotes' cytoskeleton. The networks of
actin filaments and tubulin microtubules are substrates for cells' motility and mechanics, intra …
actin filaments and tubulin microtubules are substrates for cells' motility and mechanics, intra …
Rapid assembly and collective behavior of microtubule bundles in the presence of polyamines
Microtubules (MTs) are cylindrical cytoskeleton polymers composed of α-β tubulin
heterodimers whose dynamic properties are essential to fulfill their numerous cellular …
heterodimers whose dynamic properties are essential to fulfill their numerous cellular …
Mathematical modeling of microtubule dynamics: insights into physiology and disease
Computer models of microtubule dynamics have provided the basis for many of the theories
on the cellular mechanics of the microtubules, their polymerization kinetics, and the diffusion …
on the cellular mechanics of the microtubules, their polymerization kinetics, and the diffusion …
Mean-field study of the role of lateral cracks in microtubule dynamics
G Margolin, HV Goodson, MS Alber - … E—Statistical, Nonlinear, and Soft Matter …, 2011 - APS
A link between dimer-scale processes and microtubule (MT) dynamics at macroscale is
studied by comparing simulations obtained using computational dimer-scale model with its …
studied by comparing simulations obtained using computational dimer-scale model with its …
Minimal Mechanisms of Microtubule Length Regulation in Living Cells
The microtubule cytoskeleton is responsible for sustained, long-range intracellular transport
of mRNAs, proteins, and organelles in neurons. Neuronal microtubules must be stable …
of mRNAs, proteins, and organelles in neurons. Neuronal microtubules must be stable …
Exploring the effect of end-binding proteins and microtubule targeting chemotherapy drugs on microtubule dynamic instability
Microtubules (MTs) play a key role in normal cell development and are a primary target for
many cancer chemotherapy MT targeting agents (MTAs). As such, understanding MT …
many cancer chemotherapy MT targeting agents (MTAs). As such, understanding MT …
The use of compressive sensing and peak detection in the reconstruction of microtubules length time series in the process of dynamic instability
M Mahrooghy, S Yarahmadian, V Menon… - Computers in biology …, 2015 - Elsevier
Microtubules (MTs) are intra-cellular cylindrical protein filaments. They exhibit a unique
phenomenon of stochastic growth and shrinkage, called dynamic instability. In this paper …
phenomenon of stochastic growth and shrinkage, called dynamic instability. In this paper …