Brain organoids are self-assembled three-dimensional aggregates generated from
pluripotent stem cells with cell types and cytoarchitectures that resemble the embryonic …

The assembly and maturation of the mammalian brain result from an intricate cascade of
highly coordinated developmental events, such as cell proliferation, migration, and …

Adult neurogenesis in the murine dentate gyrus occurs in a specialized microenvironment
that sustains the generation of neurons during life. To fully understand adult neurogenesis, it …

The cerebral cortex is organized into specialized sensory areas, whose initial territory is
determined by intracortical molecular determinants. Yet, sensory cortical area size appears …

For half a century now, the barrel cortex of common laboratory rodents has been an
exceptionally useful model for studying the formation of topographically organized maps …

A hundred years after Lhx2 ortholog apterous was identified as a critical regulator of wing
development in Drosophila, LIM-HD gene family members have proved to be versatile and …

In the developing cerebral cortex, sequential transcriptional programs take neuroepithelial
cells from proliferating progenitors to differentiated neurons with unique molecular identities …

Transcription factors are expressed in a dynamic fashion both in time and space during
brain development, and exert their roles by activating a cascade of multiple target genes …

Abstract Fetal Alcohol Spectrum Disorders, or FASD, represent a range of adverse
developmental conditions caused by prenatal ethanol exposure (PrEE) from maternal …

We demonstrate using conditional mutagenesis that Pbx1, with and without Pbx2+/−
sensitization, regulates regional identity and laminar patterning of the developing mouse …