Recent advances in sustainable synthesis of N-heterocycles following acceptorless dehydrogenative coupling protocol using alcohols

M Maji, D Panja, I Borthakur, S Kundu - Organic Chemistry Frontiers, 2021 - pubs.rsc.org
The synthesis of heterocycles is an emerging area of chemical research considering their
high importance in pharmaceuticals, material chemistry, and natural product synthesis. The …

Bestowal of quinazoline scaffold in anticancer drug discovery

R Das, DK Mehta, M Dhanawat - Anti-Cancer Agents in …, 2021 - ingentaconnect.com
Background: Cancer is one of the major causes of human mortality worldwide. A number of
existing antineoplastic medications and treatment regimens are already working in the field …

Microwave-Promoted Syntheses of Quinazolines and Dihydroquinazolines from 2-Aminoarylalkanone O-Phenyl Oximes

F Portela-Cubillo, JS Scott… - The Journal of organic …, 2009 - ACS Publications
A wide range of biologically active compounds contain the quinazoline ring system. A new
free-radical-based method of making functionalized quinazolines is described, which relies …

Isolation and inhibitory activity against ERK phosphorylation of hydroxyanthraquinones from rhubarb

X Zhou, B Song, L Jin, D Hu, C Diao, G Xu… - Bioorganic & Medicinal …, 2006 - Elsevier
Five hydroxyanthraquinone compounds were purified from Chinese medicinal herb rhubarb
by microwave-assisted extraction and silica gel column isolation. Their structures were …

A catalyst-and solvent-free selective approach to biologically important quinazolines and benzo [g] quinazoline

V Kumar, C Mohan, M Gupta, MP Mahajan - Tetrahedron, 2005 - Elsevier
A catalyst- and solvent-free selective approach to biologically important quinazolines and
benzo[g]quinazoline - ScienceDirect Skip to main contentSkip to article Elsevier logo Journals …

New substituted quinazoline analogs: Synthesis, anticancer evaluation and docking study

M Naziri, M Mokhtary, F Safa - Journal of Molecular Structure, 2023 - Elsevier
In this work, fifteen new substituted quinazoline analogs were synthesized in good yields
through the reaction of 7-(2-chloroethoxy)-6-methoxy-N-arylquinazoline-4-amine and …

Benzotriazepine synthesis, conformational analysis, and biological properties

SM Harvey, X Wei, D Truong… - Canadian Journal of …, 2024 - cdnsciencepub.com
Various benzotriazepine ring systems have been synthesized and examined for biological
activity. Moreover, the 1, 3, 4-benzotriazepin-2-one has been shown to act as a constrained …

Multi-component synthesis of pyrazolo [1, 5-a] quinazoline, thiazole and thiophene derivatives as cytotoxic agents

RM Mohareb, MHE Helal, AE Mayhoub… - Bulletin of the Chemical …, 2023 - ajol.info
This study demonstrated the synthesis of a number of pyrazolo [1, 5-a] quinazoline
derivatives about 24 products based on the starting material 4-(2-phenylhydrazono)-4H …

Targeting SARS-CoV-2 Polymerase with New Nucleoside Analogues

V Daikopoulou, P Apostolou, S Mourati, I Vlachou… - Molecules, 2021 - mdpi.com
Despite the fact that COVID-19 vaccines are already available on the market, there have not
been any effective FDA-approved drugs to treat this disease. There are several already …

Copper-catalyzed sequential n-arylation and aerobic oxidation: Synthesis of quinazoline derivatives

Q Liu, Y Zhao, H Fu, C Cheng - Synlett, 2013 - thieme-connect.com
A novel and efficient copper-catalyzed cascade method for the synthesis of quinazoline
derivatives has been developed. The protocol uses readily available substituted (2 …