Exposure to manganese (Mn) causes clinical signs and symptoms resembling, but not
identical to, Parkinson's disease. Since our last review on this subject in 2004, the past …

Superoxide, O2•−, is formed in all living organisms that come in contact with air, and,
depending upon its biological context, it may act as a signaling agent, a toxic species, or a …

Manganese catalases (MnCAT) and superoxide dismutases (MnSOD) deplete hydrogen
peroxide and superoxide in cells through a ping-pong mechanism involving cyclic oxidation …

Human manganese superoxide dismutase (MnSOD) is a crucial oxidoreductase that
maintains the vitality of mitochondria by converting superoxide (O2●−) to molecular oxygen …

In this review, we focus on understanding the structure–function relationships of numerous
manganese superoxide dismutase (MnSOD) mutants to investigate the role that various …

Biomaterials encounter considerable challenges in extensive bone defect regeneration. The
amelioration of outcomes may be attainable through the orchestrated modulation of both …

Pulse radiolysis is a powerful method for generating highly reduced or oxidized species and
free radicals. Combined with fast time-resolved spectroscopic measurement, we can monitor …

The Lyme disease pathogen Borrelia burgdorferi represents a novel organism in which to
study metalloprotein biology in that this spirochete has uniquely evolved with no …

Readily exchangeable water molecules are commonly found in the active sites of
oxidoreductases, yet the overwhelming majority of studies on small-molecule mimics of …

Peroxomanganese species have been proposed as key intermediates in the catalytic cycles
of both manganese enzymes and synthetic catalysts. However, many of these intermediates …