Transgenic mouse models of Alzheimer's disease: An integrative analysis

R Sanchez-Varo, M Mejias-Ortega… - International Journal of …, 2022 - mdpi.com
Alzheimer's disease (AD) constitutes the most prominent form of dementia among elderly
individuals worldwide. Disease modeling using murine transgenic mice was first initiated …

The role of glial autophagy in Alzheimer's disease

A Litwiniuk, GR Juszczak, AM Stankiewicz… - Molecular …, 2023 - nature.com
Although Alzheimer's disease is the most pervasive neurodegenerative disorder, the
mechanism underlying its development is still not precisely understood. Available data …

Myelin repair in Alzheimer's disease: a review of biological pathways and potential therapeutics

LR Hirschfeld, SL Risacher, K Nho… - Translational …, 2022 - Springer
This literature review investigates the significant overlap between myelin-repair signaling
pathways and pathways known to contribute to hallmark pathologies of Alzheimer's disease …

Oligodendrogliopathy in neurodegenerative diseases with abnormal protein aggregates: the forgotten partner

I Ferrer - Progress in neurobiology, 2018 - Elsevier
Oligodendrocytes are in contact with neurons, wrap axons with a myelin sheath that protects
their structural integrity, and facilitate nerve conduction. Oligodendrocytes also form a …

Complicated role of post-translational modification and protease-cleaved fragments of tau in Alzheimer's Disease and other tauopathies

J Yang, N Shen, J Shen, Y Yang, HL Li - Molecular Neurobiology, 2024 - Springer
Tau, a microtubule-associated protein predominantly localized in neuronal axons, plays a
crucial role in promoting microtubule assembly, stabilizing their structure, and participating …

Effect of glial cells on remyelination after spinal cord injury

H Wang, X Liu, R Li, P Zhang, Z Chu… - Neural regeneration …, 2017 - journals.lww.com
Remyelination plays a key role in functional recovery of axons after spinal cord injury. Glial
cells are the most abundant cells in the central nervous system. When spinal cord injury …

Stimulating myelin restoration with BDNF: a promising therapeutic approach for Alzheimer's disease

I Zota, K Chanoumidou, A Gravanis… - Frontiers in Cellular …, 2024 - frontiersin.org
Alzheimer's Disease (AD) is a chronic neurodegenerative disorder constituting the most
common form of dementia (60%− 70% of cases). Although AD presents majorly a …

CXCL12 induces migration of oligodendrocyte precursor cells through the CXCR4‑activated MEK/ERK and PI3K/AKT pathways

Y Tian, H Yin, X Deng, B Tang… - Molecular medicine …, 2018 - spandidos-publications.com
Demyelination is a nervous system disease in which the myelin sheaths of neurons are
damaged due to inflammatory reactions, inherited abnormalities or trauma. This damage …

Tau modulates Schwann cell proliferation, migration and differentiation following peripheral nerve injury

S Yi, Q Liu, X Wang, T Qian, H Wang… - Journal of cell …, 2019 - journals.biologists.com
Tau protein (encoded by the gene microtubule-associated protein tau, Mapt) is essential for
the assembly and stability of microtubule and the functional maintenance of the nervous …

Epidural spinal cord stimulation promotes motor functional recovery by enhancing oligodendrocyte survival and differentiation and by protecting myelin after spinal …

G Li, ZK Fan, GF Gu, ZQ Jia, QQ Zhang, JY Dai… - Neuroscience …, 2020 - Springer
Epidural spinal cord stimulation (ESCS) markedly improves motor and sensory function after
spinal cord injury (SCI), but the underlying mechanisms are unclear. Here, we investigated …