Application of human brain organoids—opportunities and challenges in modeling human brain development and neurodevelopmental diseases
S Kim, MY Chang - International journal of molecular sciences, 2023 - mdpi.com
Brain organoids are three-dimensional (3D) structures derived from human pluripotent stem
cells (hPSCs) that reflect early brain organization. These organoids contain different cell …
cells (hPSCs) that reflect early brain organization. These organoids contain different cell …
Brain plasticity and human evolution
CC Sherwood, A Gómez-Robles - annual review of anthropology, 2017 - annualreviews.org
Human behavior is shaped by social learning to an extent that is unrivaled in the natural
world. What neurobiological changes have occurred in human evolutionary history that have …
world. What neurobiological changes have occurred in human evolutionary history that have …
Widespread RNA editing dysregulation in brains from autistic individuals
SS Tran, HI Jun, JH Bahn, A Azghadi… - Nature …, 2019 - nature.com
Transcriptomic analyses of postmortem brains have begun to elucidate molecular
abnormalities in autism spectrum disorder (ASD). However, a crucial pathway involved in …
abnormalities in autism spectrum disorder (ASD). However, a crucial pathway involved in …
[HTML][HTML] Pre/post-natal exposure to microplastic as a potential risk factor for autism spectrum disorder
In common with the increase in environmental pollution in the past 10 years, there has also
been a recent increase in the prevalence of autism spectrum disorder (ASD). In this regard …
been a recent increase in the prevalence of autism spectrum disorder (ASD). In this regard …
Single-cell-resolution transcriptome map of human, chimpanzee, bonobo, and macaque brains
Identification of gene expression traits unique to the human brain sheds light on the
molecular mechanisms underlying human evolution. Here, we searched for uniquely human …
molecular mechanisms underlying human evolution. Here, we searched for uniquely human …
[HTML][HTML] Xenotransplanted human cortical neurons reveal species-specific development and functional integration into mouse visual circuits
How neural circuits develop in the human brain has remained almost impossible to study at
the neuronal level. Here, we investigate human cortical neuron development, plasticity, and …
the neuronal level. Here, we investigate human cortical neuron development, plasticity, and …
[HTML][HTML] SYNGAP1 deficiency disrupts synaptic neoteny in xenotransplanted human cortical neurons in vivo
B Vermaercke, R Iwata, K Wierda, L Boubakar… - Neuron, 2024 - cell.com
Human brain ontogeny is characterized by a considerably prolonged neotenic development
of cortical neurons and circuits. Neoteny is thought to be essential for the acquisition of …
of cortical neurons and circuits. Neoteny is thought to be essential for the acquisition of …
Species-specific maturation profiles of human, chimpanzee and bonobo neural cells
MC Marchetto, B Hrvoj-Mihic, BE Kerman, DX Yu… - elife, 2019 - elifesciences.org
Comparative analyses of neuronal phenotypes in closely related species can shed light on
neuronal changes occurring during evolution. The study of post-mortem brains of nonhuman …
neuronal changes occurring during evolution. The study of post-mortem brains of nonhuman …
Selective time-dependent changes in activity and cell-specific gene expression in human postmortem brain
As a means to understand human neuropsychiatric disorders from human brain samples, we
compared the transcription patterns and histological features of postmortem brain to fresh …
compared the transcription patterns and histological features of postmortem brain to fresh …
Comprehensive evaluation of deconvolution methods for human brain gene expression
Transcriptome deconvolution aims to estimate the cellular composition of an RNA sample
from its gene expression data, which in turn can be used to correct for composition …
from its gene expression data, which in turn can be used to correct for composition …