The field of cAMP signaling is witnessing exciting developments with the recognition that
cAMP is compartmentalized and that spatial regulation of cAMP is critical for faithful signal …

Encoding new information in the brain requires changes in synaptic strength.
Neuromodulatory transmitters can facilitate synaptic plasticity by modifying the actions and …

Brief periods of sleep loss have long-lasting consequences such as impaired memory
consolidation. Structural changes in synaptic connectivity have been proposed as a …

Post-transcriptional modifications of RNA, such as RNA methylation, can epigenetically
regulate behavior, for instance learning and memory. However, it is unclear whether RNA …

Experience-dependent learning and memory require multiple forms of plasticity at
hippocampal and cortical synapses that are regulated by N-methyl-D-aspartate receptors …

Sleep deprivation is a public health epidemic that causes wide-ranging deleterious
consequences, including impaired memory and cognition. Protein synthesis in hippocampal …

Sleep deprivation disrupts hippocampal function and plasticity. In particular, long-term
memory consolidation is impaired by sleep deprivation, suggesting that a specific critical …

A central theme in nervous system function is equilibrium: synaptic strengths wax and wane,
neuronal firing rates adjust up and down, and neural circuits balance excitation with …

The degeneration of substantia nigra (SN) dopamine (DA) neurons in sporadic Parkinson׳ s
disease (PD) is characterized by disturbed gene expression networks. Micro (mi) RNAs are …

Myocardial stress and injury invariably promote remodeling of the cardiac tissue, which is
associated with cardiomyocyte death and development of fibrosis. The fibrotic process is …