Epigenetic mechanisms and hypertension
M Liang - Hypertension, 2018 - Am Heart Assoc
DNA methylation occurs primarily at cytosine in cytosine-guanine dinucleotides (CpG) and
involves the addition of a methyl group to carbon number 5 in cytosine to form 5 …
involves the addition of a methyl group to carbon number 5 in cytosine to form 5 …
Genome-wide association studies of hypertension and several other cardiovascular diseases
Y Wang, JG Wang - Pulse, 2019 - karger.com
Genome-wide association studies (GWAS) have greatly expanded our understanding of the
genetic architecture of cardiovascular diseases in the past decade. They have revealed …
genetic architecture of cardiovascular diseases in the past decade. They have revealed …
Associations of combined genetic and lifestyle risks with incident cardiovascular disease and diabetes in the UK Biobank Study
MA Said, N Verweij, P van der Harst - JAMA cardiology, 2018 - jamanetwork.com
Importance Genetic and lifestyle factors both contribute to the risk of developing
cardiovascular disease, but whether poor health behaviors are associated with similar …
cardiovascular disease, but whether poor health behaviors are associated with similar …
Differential methylation between ethnic sub-groups reflects the effect of genetic ancestry and environmental exposures
Populations are often divided categorically into distinct racial/ethnic groups based on social
rather than biological constructs. Genetic ancestry has been suggested as an alternative to …
rather than biological constructs. Genetic ancestry has been suggested as an alternative to …
DNA methylation analysis identifies loci for blood pressure regulation
Genome-wide association studies have identified hundreds of genetic variants associated
with blood pressure (BP), but sequence variation accounts for a small fraction of the …
with blood pressure (BP), but sequence variation accounts for a small fraction of the …
Novel blood pressure locus and gene discovery using genome-wide association study and expression data sets from blood and the kidney
Elevated blood pressure is a major risk factor for cardiovascular disease and has a
substantial genetic contribution. Genetic variation influencing blood pressure has the …
substantial genetic contribution. Genetic variation influencing blood pressure has the …
Integration of human pancreatic islet genomic data refines regulatory mechanisms at type 2 diabetes susceptibility loci
Human genetic studies have emphasised the dominant contribution of pancreatic islet
dysfunction to development of Type 2 Diabetes (T2D). However, limited annotation of the …
dysfunction to development of Type 2 Diabetes (T2D). However, limited annotation of the …
Body mass index drives changes in DNA methylation: a longitudinal study
Rationale: Previous EWASs (Epigenome-Wide Association Studies) suggest that obesity
may be the cause, not a consequence, of changes in DNA methylation (DNAm). However …
may be the cause, not a consequence, of changes in DNA methylation (DNAm). However …
[HTML][HTML] Genetic predisposition to ischemic stroke
T Hachiya, Y Kamatani, A Takahashi, J Hata… - Stroke, 2017 - journals.lww.com
The prediction of genetic predispositions to ischemic stroke (IS) may allow the identification
of individuals at elevated risk and thereby prevent IS in clinical practice. Previously …
of individuals at elevated risk and thereby prevent IS in clinical practice. Previously …
Twenty-five novel loci for carotid intima-media thickness: a genome-wide association study in> 45 000 individuals and meta-analysis of> 100 000 individuals
Objective: Carotid artery intima-media thickness (cIMT) is a widely accepted marker of
subclinical atherosclerosis. Twenty susceptibility loci for cIMT were previously identified and …
subclinical atherosclerosis. Twenty susceptibility loci for cIMT were previously identified and …