Considerable information is currently available from neuroimaging, pathological, and
population-based prospective studies showing that vascular risk factors are independently …

These guidelines will be updated every four years. Vascular centres are encouraged to audit
implementations made as a result of the guidelines. Audit cycles should be repeated and …

A substantial body of evidence supports the hypothesis of a vascular component in the
pathogenesis of Alzheimer's disease (AD). Cerebral hypoperfusion and blood-brain barrier …

Background Few data on the pathology of cerebral vessel disease, dementia, and cognition
are available. We examined the association of cerebral atherosclerosis and …

Abnormalities in neuronal cholesterol homeostasis have been suspected or observed in
several neurodegenerative disorders including Alzheimer's disease, Parkinson's disease …

Cerebrovascular reactivity (CVR) is the change in cerebral blood flow (CBF) in response to a
change in a vasoactive stimulus. Paradoxical reductions in CBF in response to vasodilatory …

Objective: To evaluate whether severe carotid stenosis and related hemodynamics
impairment may increase the risk of cognitive deterioration in asymptomatic subjects …

We define cerebral vascular reactivity (CVR) as the ratio of the change in blood oxygen level-
dependent (BOLD) magnetic resonance imaging (MRI) signal (S) to an increase in blood …

Background and Purpose—Although vascular risk factors have been implicated in the
development of all-cause dementia and Alzheimer disease (AD), few studies have …

There is an extensive literature relating to factors associated with the development of
Alzheimer's disease (AD), but less is known about factors which may contribute to its …